Professor at University of Buenos Aires , Argentina.
Dr. Mariela Mercedes Gironacci is a distinguished Associate Professor in the Department of Biological Chemistry at the School of Pharmacy and Biochemistry, Buenos Aires University. With a Ph.D. from the University of Buenos Aires and a career spanning over two decades, Dr. Gironacci has made significant contributions to hypertension research. Her work focuses on the Mas receptor and its role in anti-inflammatory and antihypertensive responses. She has led multiple research projects funded by CONICET and other national and international bodies. Dr. Gironacci has received numerous awards, including the Braun Menéndez Award and the Prof. Dr. Luis Moledo Award, recognizing her excellence in hypertension research. She is an active member of professional societies, serves on editorial boards, and has delivered invited lectures globally. Her research impact is evident in her extensive publications and her leadership in advancing our understanding of the renin-angiotensin system.
Dr. Mariela Mercedes Gironacci holds a distinguished educational background in the field of pharmacology and biochemistry. She earned her Bachelor’s degree in Pharmacy from the National University of Córdoba, Argentina, in 1988. Building upon this foundation, she pursued advanced studies at the University of Buenos Aires, where she completed her Ph.D. in 1999. Her doctoral research contributed significantly to the understanding of the renin-angiotensin system, particularly in relation to hypertension. Dr. Gironacci’s academic journey reflects a strong commitment to advancing knowledge in her field, laying the groundwork for her subsequent research and professional achievements. Her education has equipped her with the expertise necessary to make substantial contributions to pharmacology and biochemistry, particularly in hypertension and cardiovascular research.
Dr. Mariela Mercedes Gironacci is an esteemed Associate Professor in the Department of Biological Chemistry at the School of Pharmacy and Biochemistry, Buenos Aires University, where she has served since March 2023. Her academic career began as an Instructor in 1991, progressing to Assistant Professor (1996-2008) and then Associate Professor (2008-2023) before her current role. Concurrently, Dr. Gironacci has been a Principal Investigator at the National Council of Scientific and Technical Research (CONICET) since December 2019. Her research focuses on hypertension and cardiovascular health, particularly the Mas receptor’s role in antihypertensive responses. Her leadership extends to serving on various editorial boards, including Hypertension and the Journal of the Argentinian Society of Hypertension, and she has held significant positions in professional societies, including the Inter-American Society of Hypertension. Her extensive experience in teaching, research, and leadership underscores her significant contributions to the field.
Dr. Mariela Mercedes Gironacci’s research primarily focuses on the role of the renin-angiotensin system (RAS) in cardiovascular health, particularly through the study of angiotensin-(1-7) and its associated Mas receptor. Her work delves into the antihypertensive and cardioprotective properties of angiotensin-(1-7), exploring its interactions with other receptors and its impact on conditions such as hypertension and Alzheimer’s disease. Dr. Gironacci’s research also examines the receptor’s involvement in inflammatory responses and its potential therapeutic targets for hypertension and neurodegenerative disorders. She is engaged in elucidating the mechanisms behind Mas receptor trafficking and its role in regulating blood pressure and cardiac function. Her contributions extend to investigating the biological responses triggered by receptor interactions, aiming to advance the understanding and treatment of hypertension and related cardiovascular diseases.
Dr. Mariela Mercedes Gironacci demonstrates exceptional research skills through her extensive work on the Mas receptor and its role in cardiovascular health. Her expertise encompasses a deep understanding of receptor regulation and trafficking, particularly in relation to antihypertensive responses. Dr. Gironacci has led pioneering studies on the depressor axis of the renin-angiotensin system, focusing on the receptor Mas and its interactions with other receptors. Her ability to design and execute complex research projects is evident in her numerous high-impact publications and successful grant applications. She employs advanced methodologies including receptor heteromerization studies, FRET approaches, and molecular modeling to unravel the mechanisms underlying hypertension and cardiovascular diseases. Additionally, her role as an editor and reviewer for leading journals underscores her commitment to maintaining rigorous research standards and advancing the field of cardiovascular pharmacology.
Awards and Recognition
Dr. Gironacci has received numerous awards for her contributions to hypertension research, including prestigious recognitions such as the Braun Menendez Award, the Luis Moledo Award, and the Prof. Dr. C. Taquini Award. These accolades reflect her excellence in research and her impact on the field. Her recognition extends to both national and international levels, highlighting her standing as a leading researcher in her field.
Conclusion
Dr. Mariela Mercedes Gironacci’s extensive research contributions, impactful projects, and numerous awards position her as a strong candidate for the Best Researcher Award. Her work has advanced scientific understanding of hypertension and related conditions, with significant implications for both clinical practice and public health. Her dedication to research, collaborative efforts, and recognition by prestigious institutions underscore her outstanding achievements in the field.
Publications Top Notes
- Circulating angiotensin-(1-7) is decreased in patients with isolated nocturnal hypertension
- Authors: J. Minetto, M.B. Cuello, F.P. Dominici, W.G. Espeche, M.M. Gironacci
- Year: 2024
- Unraveling the crosstalk between renin-angiotensin system receptors
- Authors: M.M. Gironacci, E. Bruna-Haupt
- Year: 2024
- Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat
- Authors: M.S. Landa, M.L. Schuman, M. Aisicovich, S.I. García, C.J. Pirola
- Year: 2024
- Cognitive Deficits Found in a Pro-inflammatory State are Independent of ERK1/2 Signaling in the Murine Brain Hippocampus Treated with Shiga Toxin 2 from Enterohemorrhagic Escherichia coli
- Authors: C. Berdasco, A. Pinto, M.G. Blake, J. Gironacci, J. Goldstein
- Year: 2023
- Citations: 1
- Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels
- Authors: M.G. Silva, N.L. Falcoff, G.R. Corradi, M. Nuñez, M.M. Gironacci
- Year: 2023
- Citations: 12
- Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
- Authors: M.G. Silva, F. Inserra, J. Mariani, W. Manucha, M.M. Gironacci
- Year: 2023
- Citations: 1
- Mas receptor endocytosis and signaling in health and disease
- Authors: N.L. Rukavina Mikusic, M.M. Gironacci
- Year: 2023
- Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19
- Authors: M.G. Silva, G.R. Corradi, J.I. Pérez Duhalde, W.G. Espeche, M.M. Gironacci
- Year: 2022
- Citations: 6
- Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes
- Authors: M.G. Silva, N.L. Falcoff, G.R. Corradi, G.R. Guman, M.M. Gironacci
- Year: 2022
- Citations: 4
- ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors
- Authors: A.E. Portales, E.R. Mustafá, C.I. McCarthy, M. Perelló, J. Raingo
- Year: 2022
- Citations: 8