Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

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Dr. Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

Professor at University of Virginia, United States

Dr. Lian-Wang Guo is a Professor of Biomedical Sciences at the University of Virginia with over 20 years of experience in vascular biology and biochemistry. His research primarily focuses on the role of epigenetic modulators in vascular diseases, particularly neointima-associated restenosis. He has been continuously funded by the NIH since 2012 and has published 48 peer-reviewed papers in the past six years, while also filing six patent applications. Dr. Guo’s innovative work includes developing biomimetic nanoplatforms for targeted drug delivery, which are currently in advanced trials for treating vascular conditions. His research integrates basic science with clinical applications, notably through collaboration with Dr. Craig Kent. Dr. Guo is recognized for his significant contributions to vascular epigenetics and has created a rigorous and inclusive training environment for young researchers. His work holds promise for advancing therapeutic strategies and improving clinical outcomes for vascular diseases.

Professional Profile

Education

Dr. Lian-Wang Guo’s educational background is rooted in biology and advanced plant physiology, providing a strong foundation for his extensive research career. He earned his Bachelor of Science degree in Biology from Xinjiang University in China in 1989, followed by a Master of Science in Plant Physiology from the prestigious Chinese Academy of Sciences in 1992. He continued his studies there, earning a Ph.D. in Plant Physiology and Biochemistry in 1995. Driven by a passion for genetics and biochemistry, Dr. Guo completed a postdoctoral fellowship at The Hebrew University of Jerusalem in 1998, where he broadened his research expertise in molecular biology. His educational journey reflects a commitment to understanding complex biological processes, which he has successfully applied to his pioneering work in vascular biology and epigenetics. Dr. Guo’s solid academic training has been instrumental in his innovative research contributions and leadership in biomedical sciences.

Professional Experience

Dr. Lian-Wang Guo is a tenured Professor of Biomedical Sciences at the University of Virginia, specializing in vascular biology and epigenetics. With over 20 years of research experience, Dr. Guo has developed an expertise in chromatin modulators and their role in vascular diseases, particularly in neointima-associated restenosis. He has been continuously funded by the NIH since 2012, and his prolific contributions include 48 peer-reviewed publications and multiple patents, reflecting his leadership in vascular epigenetics research. His laboratory employs advanced molecular techniques such as ChIPseq, RNAseq, bioinformatics, and innovative nanoplatforms for targeted drug delivery. Dr. Guo has also successfully fostered clinical collaborations, including the development of therapeutic interventions currently undergoing large animal trials, with preparations for human studies. A dedicated mentor, he has cultivated a rigorous training environment for students and fellows, helping them transition into independent research careers. His research has garnered numerous awards and recognition from prominent scientific organizations.

Research Interests

Lian-Wang Guo’s research interests center around the intersection of vascular biology, epigenetics, and targeted drug delivery. As a professor of Biomedical Sciences, his work focuses on understanding the role of chromatin modulators, such as EZH2, DOT1L, and BRD4, in vascular diseases, particularly neointima-associated restenosis. By uncovering how these epigenetic regulators influence disease-specific gene expression, he aims to develop precise therapeutic strategies that mitigate pathological vascular remodeling while preserving normal cellular functions. Dr. Guo is also deeply involved in translational research, advancing the use of biomimetic nanoplatforms for targeted, localized drug delivery. His lab has developed innovative nanotechnologies to deliver therapeutic agents to disease sites, aiming to enhance efficacy and minimize side effects. A key element of his research is the integration of basic science discoveries with clinical applications, as evidenced by his collaborations on vascular disease treatments currently in advanced stages of preclinical testing.

Lian-Wang Guo, Professor of Biomedical Sciences at the University of Virginia, has earned numerous prestigious awards and honors throughout his distinguished career. In 1996, he received the Award of Excellent Sci/Tech Articles from the Chinese Society of Plant Physiology. He has also been recognized with the University of Wisconsin-Madison Eye Research Institute Rapid Response Initiative Award (2008), the Morgridge Institute for Research Award (2014), and the New Investigator Award from the State of Wisconsin Partnership Program (2014). At The Ohio State University, he earned the Accelerator Award for Translation (2017). His editorial contributions include serving as Lead Guest Editor for Genes and Associate Editor for Frontiers in Cardiovascular Medicine. In 2023, he was elected as a Fellow of the American Heart Association (FAHA), and his outstanding research earned him recognition at the 2023 Research Achievement event at the University of Virginia, marking him as a leading figure in vascular biology and biomedical research.

Dr. Lian-Wang Guo’s extensive research contributions, particularly in vascular biology and epigenetics, position him as a leading scholar in biomedical sciences. His innovative work on chromatin modulators, specifically targeting epigenetic players like BRD4, EZH2, and DOT1L, has brought new insights into the treatment of neointimal-associated vascular diseases. Additionally, his development of nano-based, targeted drug delivery systems has shown promising translational potential, bridging the gap between basic science and clinical applications. With over 20 years of experience, numerous high-impact publications, NIH funding, and significant patents, Dr. Guo’s work is both cutting-edge and impactful. His mentorship of the next generation of scientists, as well as his collaborations with leading clinicians, further enhance his academic profile. While his contributions are already significant, a continued focus on clinical translation could maximize the impact of his research. Overall, Dr. Guo exemplifies the qualities of an outstanding researcher deserving of recognition.

 

Publication top noted
  • Article: Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression
    Authors: Li, J., Shen, H., Guo, L.-W.
    Year: 2024
    Citations: 0
  • Article: miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4
    Authors: Xie, X., Shirasu, T., Li, J., Guo, L.-W., Kent, K.C.
    Year: 2023
    Citations: 3
  • Article: Neointima abating and endothelium preserving — An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L
    Authors: Shirasu, T., Yodsanit, N., Li, J., Gong, S., Guo, L.-W.
    Year: 2023
    Citations: 1
  • Article: Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms
    Authors: Yodsanit, N., Shirasu, T., Huang, Y., Gong, S., Wang, B.
    Year: 2023
    Citations: 2
  • Article: Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation
    Authors: Zhang, M., Li, J., Wang, Q., Miller, C.L., Guo, L.-W.
    Year: 2023
    Citations: 3
  • Article: Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists
    Authors: Li, J., Satyshur, K.A., Guo, L.-W., Ruoho, A.E.
    Year: 2023
    Citations: 3
  • Article: Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
    Authors: Mavlyutov, T.A., Li, J., Liu, X., Pattnaik, B., Guo, L.-W.
    Year: 2022
    Citations: 4
  • Erratum: Correction: miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction (Cell Death Discovery, (2021), 7, 1, (318), 10.1038/s41420-021-00720-9)
    Authors: Xie, X., Guo, L.-W., Kent, C.K.
    Year: 2022
    Citations: 0
  • Article: Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
    Authors: Li, J., Félix-Soriano, E., Wright, K.R., Stanford, K.I., Guo, L.-W.
    Year: 2022
    Citations: 5
  • Article: SREBP1 regulates Lgals3 activation in response to cholesterol loading
    Authors: Li, J., Shen, H., Owens, G.K., Guo, L.-W.
    Year: 2022
    Citations: 9

Jaafar Abduo | Prosthodontics | Best Researcher Award

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Assoc Prof Dr. Jaafar Abduo | Prosthodontics | Best Researcher Award

Prosthodontist at Melbourne Dental School, Australia.

Dr. Jaafar Abduo is an Associate Professor of Prosthodontics at Melbourne Dental School, University of Melbourne. He holds a PhD from the University of Western Australia and has extensive experience in clinical dentistry. His research focuses on digital workflows, implant prosthodontics, and the evaluation of modern dental manufacturing techniques. Dr. Abduo has published over 90 peer-reviewed papers and has a significant impact on the field, with an h-index of 30 and more than 4,600 citations. He collaborates with leading dental companies and has been awarded multiple national and international grants. Additionally, he serves on various academic and professional committees, contributing to research ethics, curriculum development, and continuing education. Dr. Abduo’s work has been presented at major international conferences, and his innovations have influenced both academic research and clinical practices in prosthodontics globally.

Profile
Education

Dr. Jaafar Abduo’s educational background is distinguished by his extensive training in dentistry and prosthodontics. He earned his Doctor of Philosophy (PhD) by publication from the University of Western Australia in 2016, which reflects his significant contributions to dental research. Prior to this, he completed the Doctor of Clinical Dentistry in Prosthodontics (DClinDent) at the University of Otago, Dunedin, New Zealand, in 2010, underscoring his specialized expertise in prosthodontics. His journey began with a Bachelor of Dental Surgery with credit from the University of Otago in 2004. Additionally, he achieved Membership of the Royal Australasian College of Dental Surgeons in Prosthodontics (MRACDS Pros) through examination in Sydney, Australia, in 2011. This robust educational foundation has equipped Dr. Abduo with the knowledge and skills necessary to advance the field of dental prosthetics.

Professional Experience

Dr. Jaafar Abduo is an accomplished prosthodontist and Associate Professor at the Melbourne Dental School, University of Melbourne. Since January 2020, he has held the position of Associate Professor (Level D) in Prosthodontics, where he also serves as the Convenor for the Doctor of Clinical Dentistry (Prosthodontics) program and the Postgraduate Diploma in Clinical Dentistry (Implants). Dr. Abduo’s career at the Melbourne Dental School began in 2013 as a Senior Lecturer (Level C) in Prosthodontics. Alongside his academic roles, he has been a practicing specialist prosthodontist in private practice since 2011. Dr. Abduo’s expertise spans removable prosthodontics, complex rehabilitation, and implant prosthodontics, and he is actively involved in both teaching and research. His work is well-regarded, with numerous peer-reviewed publications and significant contributions to advancing dental education and clinical practice.

Research Interest

Dr. Jaafar Abduo’s research interests are centered around advancing prosthodontics, with a particular focus on digital dentistry and modern manufacturing techniques. He explores the development and evaluation of digital workflows for diagnostics, conventional, removable, and implant prosthodontics, aiming to improve accuracy and efficiency in dental treatments. His work also includes randomized controlled trials to assess the clinical outcomes of materials such as monolithic zirconia and metal-ceramic implant crowns. Additionally, Dr. Abduo is interested in optimizing digital scanning methods for natural teeth, soft tissue, and implants. His biomechanical studies on implant and natural tooth comparisons, along with his research on the durability of dental prosthetics, contribute to enhancing the quality and longevity of dental restorations. Through his research, Dr. Abduo seeks to bridge the gap between clinical practice and technological advancements, ultimately improving patient outcomes in prosthodontics.

Research Skills

Dr. Jaafar Abduo possesses a comprehensive set of research skills that have greatly contributed to the field of prosthodontics. His expertise lies in digital dentistry, particularly in developing and optimizing digital workflows for various prosthodontic procedures, including implant and removable prosthodontics. He is proficient in conducting randomized controlled trials and biomechanical evaluations, ensuring the clinical efficacy and durability of dental materials and techniques. Dr. Abduo’s collaboration with industry leaders showcases his ability to bridge academic research with practical applications, enhancing dental treatment outcomes. His supervisory experience, guiding numerous Doctor of Clinical Dentistry and postgraduate students, demonstrates his mentorship skills and commitment to advancing dental education. Additionally, Dr. Abduo has secured multiple research grants, highlighting his capability in securing funding and managing large-scale projects. His strong publication record, with a high h-index and numerous citations, underscores his ability to disseminate research findings effectively and contribute to the broader scientific community.

Awards and Recognition

Dr. Abduo has received several prestigious awards and grants, including the F. A. Kernott Early Career Researcher Award and various grants from the Australian Dental Research Foundation and international sources. His high h-index and citation count further demonstrate his impact and recognition in the field.

Conclusion

Dr. Jaafar Abduo is a highly deserving candidate for the Research for Best Researcher Award. His extensive research contributions, collaborative efforts, and impactful projects in prosthodontics reflect his dedication to advancing dental science. His work has both national and international significance, making him a prominent figure in the field of dental research.

Publications Top Notes

  • “Muscle and joint mechanics during maximum force biting following total temporomandibular joint replacement surgery”
    • Authors: Woodford, S.C., Robinson, D.L., Abduo, J., Lee, P.V.S., Ackland, D.C.
    • Year: 2024
    • Citations: 0
  • “Effect of prefabricated immediate interim prosthesis design and insertion workflow on seating accuracy on implants placed via static computer-assisted implant surgery: A cross-sectional in vitro study”
    • Authors: Abduo, J., Lau, D.
    • Year: 2024
    • Citations: 0
  • “Influence of Implant Adjacent Teeth on the Accuracy of Digital Impression”
    • Authors: Abduo, J., El-Haddad, H.
    • Year: 2024
    • Citations: 0
  • “Seating accuracy of removable partial denture frameworks fabricated by different digital workflows in comparison to conventional workflow”
    • Authors: Korkes, A., Jomaa, J., Kavouris, A., Law, K.H.J., Abduo, J.
    • Year: 2024
    • Citations: 0
  • “Effect of pilot-guided implant placement concept on the accuracy of osteotomy preparation and implant placement”
    • Authors: Sharma, S., Tan, E., Tran, B., Teo, J., Abduo, J.
    • Year: 2024
    • Citations: 0
  • “The Effect of Various Lasers on the Bond Strength Between Orthodontic Brackets and Dental Ceramics: A Systematic Review and Meta-Analysis”
    • Authors: Mosaddad, S.A., Abduo, J., Zakizade, M., Tebyaniyan, H., Hussain, A.
    • Year: 2024
    • Citations: 2
  • “Accuracy of Static Computer-Assisted Implant Placement in Posterior Edentulous Areas with Different Levels of Tooth-Support by Novice Clinicians”
    • Authors: Abduo, J., Lau, D.
    • Year: 2023
    • Citations: 0
  • “Kinematics of the jaw following total temporomandibular joint replacement surgery”
    • Authors: Woodford, S.C., Robinson, D.L., Abduo, J., Lee, P.V.S., Ackland, D.C.
    • Year: 2023
    • Citations: 3
  • “Marginal Accuracy of Monolithic and Veneered Zirconia Crowns Fabricated by Conventional and Digital Workflows”
    • Authors: Abduo, J., Ho, G., Centorame, A., Le, P., Ngo, C.
    • Year: 2023
    • Citations: 3
  • “Measuring tooth movement with treatment using the Dahl principle: An observational study”
    • Authors: Bhai, K., Judge, R., Abduo, J., Palamara, J.
    • Year: 2023
    • Citations: 1

Mariela Gironacci | Molecular Biology | Best Researcher Award

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Prof. Mariela Gironacci | Molecular Biology | Best Researcher Award

Professor at University of Buenos Aires , Argentina.

Dr. Mariela Mercedes Gironacci is a distinguished Associate Professor in the Department of Biological Chemistry at the School of Pharmacy and Biochemistry, Buenos Aires University. With a Ph.D. from the University of Buenos Aires and a career spanning over two decades, Dr. Gironacci has made significant contributions to hypertension research. Her work focuses on the Mas receptor and its role in anti-inflammatory and antihypertensive responses. She has led multiple research projects funded by CONICET and other national and international bodies. Dr. Gironacci has received numerous awards, including the Braun Menéndez Award and the Prof. Dr. Luis Moledo Award, recognizing her excellence in hypertension research. She is an active member of professional societies, serves on editorial boards, and has delivered invited lectures globally. Her research impact is evident in her extensive publications and her leadership in advancing our understanding of the renin-angiotensin system.

Profile
Education

Dr. Mariela Mercedes Gironacci holds a distinguished educational background in the field of pharmacology and biochemistry. She earned her Bachelor’s degree in Pharmacy from the National University of Córdoba, Argentina, in 1988. Building upon this foundation, she pursued advanced studies at the University of Buenos Aires, where she completed her Ph.D. in 1999. Her doctoral research contributed significantly to the understanding of the renin-angiotensin system, particularly in relation to hypertension. Dr. Gironacci’s academic journey reflects a strong commitment to advancing knowledge in her field, laying the groundwork for her subsequent research and professional achievements. Her education has equipped her with the expertise necessary to make substantial contributions to pharmacology and biochemistry, particularly in hypertension and cardiovascular research.

Professional Experience

Dr. Mariela Mercedes Gironacci is an esteemed Associate Professor in the Department of Biological Chemistry at the School of Pharmacy and Biochemistry, Buenos Aires University, where she has served since March 2023. Her academic career began as an Instructor in 1991, progressing to Assistant Professor (1996-2008) and then Associate Professor (2008-2023) before her current role. Concurrently, Dr. Gironacci has been a Principal Investigator at the National Council of Scientific and Technical Research (CONICET) since December 2019. Her research focuses on hypertension and cardiovascular health, particularly the Mas receptor’s role in antihypertensive responses. Her leadership extends to serving on various editorial boards, including Hypertension and the Journal of the Argentinian Society of Hypertension, and she has held significant positions in professional societies, including the Inter-American Society of Hypertension. Her extensive experience in teaching, research, and leadership underscores her significant contributions to the field.

Research Interest

Dr. Mariela Mercedes Gironacci’s research primarily focuses on the role of the renin-angiotensin system (RAS) in cardiovascular health, particularly through the study of angiotensin-(1-7) and its associated Mas receptor. Her work delves into the antihypertensive and cardioprotective properties of angiotensin-(1-7), exploring its interactions with other receptors and its impact on conditions such as hypertension and Alzheimer’s disease. Dr. Gironacci’s research also examines the receptor’s involvement in inflammatory responses and its potential therapeutic targets for hypertension and neurodegenerative disorders. She is engaged in elucidating the mechanisms behind Mas receptor trafficking and its role in regulating blood pressure and cardiac function. Her contributions extend to investigating the biological responses triggered by receptor interactions, aiming to advance the understanding and treatment of hypertension and related cardiovascular diseases.

Research Skills

Dr. Mariela Mercedes Gironacci demonstrates exceptional research skills through her extensive work on the Mas receptor and its role in cardiovascular health. Her expertise encompasses a deep understanding of receptor regulation and trafficking, particularly in relation to antihypertensive responses. Dr. Gironacci has led pioneering studies on the depressor axis of the renin-angiotensin system, focusing on the receptor Mas and its interactions with other receptors. Her ability to design and execute complex research projects is evident in her numerous high-impact publications and successful grant applications. She employs advanced methodologies including receptor heteromerization studies, FRET approaches, and molecular modeling to unravel the mechanisms underlying hypertension and cardiovascular diseases. Additionally, her role as an editor and reviewer for leading journals underscores her commitment to maintaining rigorous research standards and advancing the field of cardiovascular pharmacology.

Awards and Recognition

Dr. Gironacci has received numerous awards for her contributions to hypertension research, including prestigious recognitions such as the Braun Menendez Award, the Luis Moledo Award, and the Prof. Dr. C. Taquini Award. These accolades reflect her excellence in research and her impact on the field. Her recognition extends to both national and international levels, highlighting her standing as a leading researcher in her field.

Conclusion

Dr. Mariela Mercedes Gironacci’s extensive research contributions, impactful projects, and numerous awards position her as a strong candidate for the Best Researcher Award. Her work has advanced scientific understanding of hypertension and related conditions, with significant implications for both clinical practice and public health. Her dedication to research, collaborative efforts, and recognition by prestigious institutions underscore her outstanding achievements in the field.

Publications Top Notes

  1. Circulating angiotensin-(1-7) is decreased in patients with isolated nocturnal hypertension
    • Authors: J. Minetto, M.B. Cuello, F.P. Dominici, W.G. Espeche, M.M. Gironacci
    • Year: 2024
  2. Unraveling the crosstalk between renin-angiotensin system receptors
    • Authors: M.M. Gironacci, E. Bruna-Haupt
    • Year: 2024
  3. Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat
    • Authors: M.S. Landa, M.L. Schuman, M. Aisicovich, S.I. García, C.J. Pirola
    • Year: 2024
  4. Cognitive Deficits Found in a Pro-inflammatory State are Independent of ERK1/2 Signaling in the Murine Brain Hippocampus Treated with Shiga Toxin 2 from Enterohemorrhagic Escherichia coli
    • Authors: C. Berdasco, A. Pinto, M.G. Blake, J. Gironacci, J. Goldstein
    • Year: 2023
    • Citations: 1
  5. Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels
    • Authors: M.G. Silva, N.L. Falcoff, G.R. Corradi, M. Nuñez, M.M. Gironacci
    • Year: 2023
    • Citations: 12
  6. Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
    • Authors: M.G. Silva, F. Inserra, J. Mariani, W. Manucha, M.M. Gironacci
    • Year: 2023
    • Citations: 1
  7. Mas receptor endocytosis and signaling in health and disease
    • Authors: N.L. Rukavina Mikusic, M.M. Gironacci
    • Year: 2023
  8. Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19
    • Authors: M.G. Silva, G.R. Corradi, J.I. Pérez Duhalde, W.G. Espeche, M.M. Gironacci
    • Year: 2022
    • Citations: 6
  9. Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes
    • Authors: M.G. Silva, N.L. Falcoff, G.R. Corradi, G.R. Guman, M.M. Gironacci
    • Year: 2022
    • Citations: 4
  10. ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors
    • Authors: A.E. Portales, E.R. Mustafá, C.I. McCarthy, M. Perelló, J. Raingo
    • Year: 2022
    • Citations: 8