Itamar Willner | Medicinal Chemistry | Excellence in Research Award

Prof. Itamar Willner | Medicinal Chemistry | Excellence in Research Award

Professor from The Hebrew University of Jerusalem, Israel

Professor Itamar Willner is a distinguished Israeli chemist renowned for his pioneering contributions to supramolecular chemistry, nanotechnology, and nanobiotechnology. Born in January 1947, he has been a faculty member at the Hebrew University of Jerusalem since 1981 and was appointed as a full professor in 1986. His research has significantly advanced the understanding and application of molecular self-assembly, DNA nanotechnology, and bio-hybrid systems. With over 890 scientific publications and more than 100,000 citations, Professor Willner is among the most cited chemists globally, reflecting the profound impact of his work on the scientific community. His innovative approaches have led to the development of DNA-based molecular machines, logic gates, and dynamic networks, bridging the gap between chemistry, biology, and materials science. Throughout his career, he has received numerous prestigious awards, including the Israel Prize in Chemistry, the Rothschild Prize, and the EMET Prize, acknowledging his exceptional contributions to science. Professor Willner’s leadership extends beyond research; he has played pivotal roles in various scientific committees and editorial boards, fostering international collaborations and mentoring the next generation of scientists. His work continues to influence diverse fields, from artificial photosynthesis to smart materials, underscoring his status as a leading figure in contemporary chemistry.

Professional Profile

Education

Professor Willner’s academic journey commenced with a B.Sc. in Chemistry and Physics from the Hebrew University of Jerusalem, completed with distinction. He further pursued an M.Sc. in Chemistry at the same institution, again graduating with distinction. In 1978, he earned his Ph.D. in Physical Organic Chemistry from the Hebrew University, presenting a thesis titled “Novel Series of Polycyclic Aromatic Ions: Aromaticity Structure Relationships,” which was approved summa cum laude. Following his doctoral studies, Professor Willner undertook postdoctoral research at the University of California, Berkeley, from 1978 to 1980, working under the mentorship of Professor Melvin Calvin. This period was instrumental in shaping his future research directions, particularly in the realms of photochemistry and molecular electronics. His comprehensive educational background laid a robust foundation for his subsequent groundbreaking work in chemistry, enabling him to integrate principles from various sub-disciplines and pioneer interdisciplinary research approaches. The rigorous training and diverse academic experiences he acquired during his formative years have been pivotal in his development as a leading scientist in the field.

Professional Experience

Professor Willner’s professional career is marked by a series of esteemed academic and research positions. After completing his postdoctoral fellowship at UC Berkeley, he served as a Staff Scientist and Adjunct Assistant Professor at the same institution from 1980 to 1981. In 1981, he returned to the Hebrew University of Jerusalem as a Senior Lecturer in the Institute of Chemistry. His academic progression continued with his promotion to Associate Professor in 1983 and subsequently to Full Professor in 1986, a position he holds to this day. Beyond his teaching and research responsibilities, Professor Willner has held several significant administrative roles, including Head of the Institute of Chemistry and Chairman of the Natural Sciences Division of the Israel Academy of Sciences and Humanities. He has also been an active member of numerous scientific advisory boards and editorial committees, contributing to the advancement of chemical sciences globally. His professional journey reflects a steadfast commitment to scientific excellence, education, and leadership within the academic community.

Research Interests

Professor Willner’s research interests are deeply rooted in the exploration of supramolecular chemistry, nanotechnology, and biomolecular systems. His work focuses on the design and synthesis of functional nanostructures, particularly those involving DNA nanotechnology, nanoenzymes, and stimuli-responsive materials. He has been instrumental in developing DNA-based molecular machines and logic gates, contributing to the field of molecular computing. His research extends to the construction of bio-nano hybrid systems, integrating biomacromolecules with inorganic nanoparticles to create novel catalytic and sensing platforms. Additionally, Professor Willner has investigated artificial photosynthesis, aiming to mimic natural energy conversion processes for sustainable applications. His interdisciplinary approach combines principles from chemistry, biology, and materials science, leading to innovations in drug delivery systems, biosensors, and smart materials. Through his extensive research, he continues to push the boundaries of molecular design and functional material development.

Research Skills

Professor Willner possesses a diverse set of research skills that have enabled him to make significant contributions to the field of chemistry. His expertise includes the synthesis and characterization of supramolecular assemblies, development of DNA-based nanostructures, and fabrication of bio-nano hybrid systems. He is proficient in employing various spectroscopic and electrochemical techniques to analyze the properties and behaviors of complex molecular systems. His skills extend to the design of molecular machines and logic devices, leveraging the unique properties of nucleic acids and proteins. Furthermore, Professor Willner is adept at integrating biological components with inorganic materials to create functional interfaces for sensing and catalytic applications. His ability to navigate and combine multiple scientific disciplines has been crucial in advancing research in nanobiotechnology and molecular electronics. These competencies have not only facilitated his own research endeavors but have also positioned him as a mentor and leader in the scientific community.

Awards and Honors

Throughout his illustrious career, Professor Willner has received numerous awards and honors recognizing his outstanding contributions to science. Notably, he was awarded the Israel Prize in Chemistry in 2002, one of the country’s highest honors. His accolades also include the Rothschild Prize in Chemistry (2008), the EMET Prize in Chemistry (2008), and the Max Planck Research Award for International Cooperation (1998). He has been elected as a Fellow of the American Association for the Advancement of Science (1996) and the Royal Society of Chemistry (2009). His membership in prestigious academies includes the Israel Academy of Sciences and Humanities (2002), the European Academy of Sciences and Arts (2004), and the German National Academy of Sciences Leopoldina (2009). These honors reflect his significant impact on the scientific community and his role in advancing chemical research on a global scale.

Conclusion

Professor Itamar Willner’s career embodies the pinnacle of scientific achievement and innovation. His extensive research in supramolecular chemistry, nanotechnology, and biomolecular systems has not only expanded the frontiers of chemical science but has also paved the way for practical applications in medicine, energy, and materials science. His interdisciplinary approach and ability to integrate complex systems have resulted in groundbreaking developments, such as DNA-based molecular machines and artificial photosynthetic systems. Beyond his research, Professor Willner’s commitment to education and mentorship has cultivated a new generation of scientists, further amplifying his impact. His numerous awards and memberships in esteemed scientific academies underscore the global recognition of his contributions. As a leading figure in contemporary chemistry, Professor Willner continues to inspire and drive innovation, solidifying his legacy as a pioneer and visionary in the scientific community.

Publications Top Notes

  • Title: Integrated nanoparticle–biomolecule hybrid systems: synthesis, properties, and applications
    Authors: E. Katz, I. Willner
    Journal: Angewandte Chemie International Edition 43(45), 6042–6108
    Citations: 3189
    Year: 2004

  • Title: Nanoparticle arrays on surfaces for electronic, optical, and sensor applications
    Authors: A.N. Shipway, E. Katz, I. Willner
    Journal: ChemPhysChem 1(1), 18–52
    Citations: 3175
    Year: 2000

  • Title: Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: routes to impedimetric immunosensors, DNA‐sensors, and enzyme biosensors
    Authors: E. Katz, I. Willner
    Journal: Electroanalysis
    Citations: 1648
    Year: 2003

  • Title: “Plugging into enzymes”: Nanowiring of redox enzymes by a gold nanoparticle
    Authors: Y. Xiao, F. Patolsky, E. Katz, J.F. Hainfeld, I. Willner
    Journal: Science 299(5614), 1877–1881
    Citations: 1520
    Year: 2003

  • Title: Diverse applications of nanomedicine
    Authors: B. Pelaz, C. Alexiou, R.A. Alvarez-Puebla, F. Alves, A.M. Andrews, S. Ashraf, …
    Journal: ACS Nano 11(3), 2313–2381
    Citations: 1381
    Year: 2017

  • Title: Integration of layered redox proteins and conductive supports for bioelectronic applications
    Authors: I. Willner, E. Katz
    Journal: Angewandte Chemie International Edition 39(7), 1180–1218
    Citations: 1309
    Year: 2000

  • Title: Biomolecule‐functionalized carbon nanotubes: applications in nanobioelectronics
    Authors: E. Katz, I. Willner
    Journal: ChemPhysChem 5(8), 1084–1104
    Citations: 1089
    Year: 2004

  • Title: Semiconductor quantum dots for bioanalysis
    Authors: R. Gill, M. Zayats, I. Willner
    Journal: Angewandte Chemie International Edition 47(40), 7602–7625
    Citations: 1026
    Year: 2008

  • Title: Electronic aptamer‐based sensors
    Authors: I. Willner, M. Zayats
    Journal: Angewandte Chemie International Edition 46(34), 6408–6418
    Citations: 912
    Year: 2007

  • Title: Electroanalytical and bioelectroanalytical systems based on metal and semiconductor nanoparticles
    Authors: E. Katz, I. Willner, J. Wang
    Journal: Electroanalysis
    Citations: 912
    Year: 2004

Xin Wang | Pharmaceutical Science | Best Researcher Award

Assoc Prof Dr. Xin Wang | Pharmaceutical Science | Best Researcher Award

Assoc. Professor and PhD supervisor of Shanghai Jiao Tong University, China.

Xin Wang is a Tenure-Track Associate Professor at Shanghai Jiao Tong University, specializing in pharmaceutical and biomedical analysis. He earned his Ph.D. in Analytical Chemistry from Peking University and completed postdoctoral work at MIT and UC Berkeley. His research focuses on mass spectrometry, metabolomics, and proteomics, with key projects including drug metabolism analysis, human neurogenesis studies, and advanced sample preparation techniques. Wang’s contributions have garnered several awards, such as the Shanghai Pujiang Talent Plan Award and recognition at MIT. His expertise in analytical techniques and innovative methods has significantly impacted both academic research and industry practices.

Professional Profiles:

Education

Xin Wang completed his B.Sc. in Chemistry at Wuhan University, China, in 2010. He pursued his Ph.D. in Analytical Chemistry at Peking University, graduating in 2015. Following his doctoral studies, Dr. Wang undertook postdoctoral research at the Massachusetts Institute of Technology (MIT) from 2015 to 2018. Since 2020, he has been serving as a Tenure-Track Associate Professor at the School of Pharmaceutical Sciences, Shanghai Jiao Tong University, China.

Professional Experience

Xin Wang’s professional experience includes a significant role as a Tenure-Track Associate Professor at the School of Pharmaceutical Sciences, Shanghai Jiao Tong University, where he has been since 2020. Before this, he was a Senior Postdoctoral Associate at MIT’s Department of Biological Engineering from 2018 to 2019, and a Postdoctoral Associate in the same department from 2015 to 2018. His earlier academic journey includes a Ph.D. in Analytical Chemistry from Peking University, where he also worked as a Visiting Graduate Student at UC Berkeley.

Research Interest

Xin Wang’s research interests are at the forefront of pharmaceutical and biomedical analysis, emphasizing the use of advanced analytical techniques. His work primarily focuses on mass spectrometry and its applications in drug metabolism and toxicity testing, aiming to replace traditional trials with in vitro human systems. He is also deeply engaged in metabolomics and proteomics, using these techniques to unravel metabolic features in human neurogenesis and other physiological processes. Wang has developed innovative methods in solid-phase microextraction to enhance the sensitivity and accuracy of analyzing low-molecular-mass compounds. His research integrates these areas to advance understanding in drug testing, biomarker discovery, and the mechanistic insights into human health and disease. This multidisciplinary approach not only pushes the boundaries of analytical chemistry but also contributes to more effective and efficient drug development and disease treatment strategies.

Award and Honors

Xin Wang has received several prestigious awards and honors throughout his career. In 2023, he was recognized as an Outstanding Individual with Exceptional Contributions in Education by the School of Pharmacy at Shanghai Jiao Tong University. He also won the Second Prize in the Young Professor Teaching Skills Competition at Shanghai Jiao Tong University in 2022. Wang’s accolades include the Shanghai Overseas High-Level Talent Program Award and the Shanghai Pujiang Talent Plan Award, both in 2020. In 2016, he earned First Place in the MIT Center for Environmental Health Sciences Session. Additionally, he was awarded the First Prize in the Science and Technology Award from the China Association for Instrumental Analysis in 2015. Earlier achievements include the Aoqing Tang Scholarship (2015), the Brilliance Scholarship (2014), and multiple awards for his graduate research and innovation.

Research Skills

Xin Wang possesses advanced research skills in several key areas of analytical and biomedical science. His expertise includes pharmaceutical and biomedical analysis, utilizing techniques such as mass spectrometry, metabolomics, and proteomics to study complex biological systems. He is proficient in solid-phase microextraction and has developed innovative methods for capturing and quantifying low-molecular-mass compounds. Wang’s work with time-dependent metabolomics and LC-MS-based quantitation reflects his ability to apply cutting-edge analytical techniques to understand human neurogenesis and drug metabolism. His research in automated sample preparation and ambient mass spectrometry demonstrates his skills in developing novel methodologies for high-sensitivity detection and analysis. Wang’s contributions to bioanalytical strategies and experimental design have been recognized and published in top scientific journals, showcasing his ability to push the boundaries of current research methodologies.

Publications

  1. “Mass spectrometry‐based metabolomics for the investigation of antibiotic–bacterial interactions”
    • Authors: Xin Wang
    • Year: 2024
  2. “A new approach towards highly sensitive detection of endogenous N-acetylaspartic acid, N-acetylglutamic acid, and N-acetylaspartylglutamic acid in brain tissues based on strong anion exchange monolith microextraction coupled with UHPLC-MS/MS”
    • Authors: Xin Wang
    • Year: 2024
  3. “Mass spectrometry-based quantitation combined with time-dependent metabolomics to discover metabolic features in human neurogenesis using neural constructs generated from neural progenitor cells”
    • Authors: Xin Wang
    • Year: 2023
  4. “Mass spectrometry analysis of S-nitrosylation of proteins and its role in cancer, cardiovascular and neurodegenerative diseases”
    • Authors: Xin Wang
    • Year: 2022
  5. “Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide”
    • Authors: Xin Wang
    • Year: 2020
  6. “Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics”
    • Authors: Xin Wang
    • Year: 2019
  7. “Automated Online Solid-Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols”
    • Authors: Xin Wang
    • Year: 2018
  8. “Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function”
    • Authors: Xin Wang
    • Year: 2018
  9. “Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry”
    • Authors: Xin Wang
    • Year: 2017
  10. “Polymer‐based monolithic column with incorporated chiral metal–organic framework for enantioseparation of methyl phenyl sulfoxide using nano‐liquid chromatography”
    • Authors: Xin Wang
    • Year: 2016