Prof. Salvatore De-Simone | Diagnostic | Best Researcher Award

The individual holds a degree in Biological Sciences (Medical Modality) from the State University of Rio de Janeiro, with further qualifications including a master’s and Ph.D. in Biochemistry from the Federal University of Rio de Janeiro, and Postdoctoral studies at New York University and the European Molecular Biology Laboratory (EMBL). They have served as a Professor of Biochemistry at the Federal Fluminense University and as Head of the Laboratory of Protein and Peptide Biochemistry at the Oswaldo Cruz Institute. Currently, they specialize in Science, Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS) and are a Scientist of Our State (FAPERJ) and a researcher at CNPq. Their research focuses on Biochemistry and Immunology, particularly in the biotechnology of infectious and parasitic agents. They work on defining the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for human and animal health. They are involved in the development and improvement of (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Their group has contributed to determining the complete or partial epitopes of various viruses, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Bank. They have also developed inputs and diagnostic methodologies for various pathologies.

Professional Profiles:

• Scopus Profile
• Google scholar
• ORCID Profile

🎓 Education

Ph.D. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1981-1986. M.Sc. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1978-1980. B.Sc. in Biological Sciences (Medical Modality), State University of Rio de Janeiro, Brazil, 1973-1976. Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Germany, 1990. Postdoctoral Fellow, New York University, USA, 1988-1989. Postdoctoral Fellow, Hayem Center, St. Louis Hospital, France, 1988

🔬 Professional Experience

Specialist in Science & Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS), Brazil, 2012-present. Scientist of Our State (FAPERJ), Brazil. Researcher, CNPq, Brazil. Professor of Biochemistry, Universidade Federal Fluminense, Brazil. Head of the Laboratory of Protein and Peptide Biochemistry, Instituto Oswaldo Cruz, Brazil

💼 Other Positions and Activities

Member of the National Network of Experts in Zika and Related Diseases (RENEZIKA), Brazil. Member of the Rio Health Network (FAPERJ), Brazil. Member of the Integrated Chagas Disease Program and National Institute of Science and Technology in Neglected Diseases (INCT-IDPN), Brazil. Editorial Board Member of 2 international journals. Reviewer for over 90 scientific journals

🏆 Achievements

Defined the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for Human and animal Health. Developed and improved (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Determined the complete or partial epitopes of various viruses, including COVID-19, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Database (Immune Epitope Database and Analysis Resource (NIAID) of the National Institute of Health, USA). Developed diagnostic inputs and methodologies for various pathologies

Publications:

1. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
   • Authors: V De Rosa, M Galgani, A Porcellini, A Colamatteo, M Santopaolo, …
   • Year: 2015
   • Citations: 338
2. Occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil
   • Authors: VEP Martins, CH Alencar, MT Kamimura, FM de Carvalho Araujo, …
   • Year: 2012
   • Citations: 191
3. Acinetobacter baumannii Infections in Times of COVID-19 Pandemic
   • Authors: K Rangel, TPG Chagas, SG De-Simone
   • Year: 2021
   • Citations: 122
4. Isolation and partial characterization of a novel lectin from Talisia esculenta seeds that interferes with fungal growth
   • Authors: MF Maria das Graças, VM Gomes, RE Corsini, OLT Machado, …
   • Year: 2002
   • Citations: 106
5. Partial purification and characterization of digestive trypsin-like proteases from the velvet bean caterpillar, Anticarsia gemmatalis
   • Authors: MGA Oliveira, SG De Simone, LP Xavier, RNC Guedes
   • Year: 2005
   • Citations: 96
6. Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling
   • Authors: M Galgani, V De Rosa, S De Simone, A Leonardi, U D’Oro, G Napolitani, …
   • Year: 2004
   • Citations: 61
7. B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3α (PvMSP-3α) in malaria exposed individuals from …
   • Authors: JC Lima-Junior, J Jiang, RN Rodrigues-da-Silva, DM Banic, TM Tran, …
   • Year: 2011
   • Citations: 59
8. Immunome and venome of Bothrops jararacussu: a proteomic approach to study the molecular immunology of snake toxins
   • Authors: C Correa-Netto, R Teixeira-Araujo, AS Aguiar, AR Melgarejo, …
   • Year: 2010
   • Citations: 56
9. Oligopeptidase B from L. amazonensis: molecular cloning, gene expression analysis and molecular model
   • Authors: HL de Matos Guedes, MPD Carneiro, DCO Gomes, B Rossi-Bergmanmn, …
   • Year: 2007
   • Citations: 55
10. Characterization of an extracellular serine protease of Leishmania (Leishmania) amazonensis
    • Authors: RE Da Silva-Lopez, MGP Coelho, SG De Simone
    • Year: 2005
    • Citations: 54