Keiko Unno | Brain Function | Best Researcher Award

Dr. Keiko Unno | Brain Function | Best Researcher Award

Doctorate and Tea Sciense Center,  Japan

Dr. Keiko Unno is a renowned researcher in the field of pharmaceutical sciences with a particular focus on brain health and the impact of dietary compounds. With an educational background from Shizuoka College of Pharmacy and the University of Shizuoka, she has dedicated her career to exploring the beneficial effects of green tea and other compounds on brain function and aging. Her extensive research includes studying the impact of green tea on brain aging, the potential of dietary DNA to reduce stress, and the role of coffee polyphenols in preventing oxidative damage. Dr. Unno has been recognized for her contributions with several prestigious awards, including the Society of Tea Science Young Researcher’s Award and the World Green Tea Association’s O-CHA Pioneer Award. Currently, she serves as a Visiting Associate Professor at the Tea Science Center, University of Shizuoka, continuing her impactful research.

Profile
Education

Dr. Keiko Unno obtained her Bachelor of Science (B.S.) degree from Shizuoka College of Pharmacy in 1976. She continued her academic journey and earned a Ph.D. from the University of Shizuoka in 1994, where her research focused on areas pertinent to pharmaceutical sciences.

Professional Experience

Dr. Unno began her career as a Research Associate at Shizuoka College of Pharmacy in 1976, where she worked until 1987. Following this, she joined the University of Shizuoka’s School of Pharmaceutical Sciences, where she held various positions including Research Associate, Assistant Professor, and Associate Professor from 1987 to 2019. In 2019, she transitioned to her current role as a Visiting Associate Professor at the Tea Science Center, University of Shizuoka. Her professional trajectory highlights her extensive experience in pharmaceutical sciences and her specialization in the effects of tea and related compounds on health.

Research Interests

Dr. Unno’s research primarily focuses on:

  1. Prevention Against Brain Dysfunction with Aging: Investigating methods to mitigate cognitive decline associated with aging.
  2. Effect of Psychosocial Stress on Brain Function: Examining how stress impacts brain health and function.
Author Metric

Dr. Unno has authored several notable publications, reflecting her research contributions in the field:

  • 2024: “DNA Mutagenicity of Hydroxyhydroquinone in Roasted Coffee Products and Its Suppression by Chlorogenic Acid, a Coffee Polyphenol, in Oxidative-Damage-Sensitive SAMP8 Mice” in International Journal of Molecular Sciences (25:720).
  • 2023: “Stress Reduction Potential in Mice Ingesting DNA from Salmon Milt” in Biology (12:978).
  • 2022: “Improvement of Depressed Mood with Green Tea Intake” in Nutrients (14:2949).
  • 2021: “Green Tea Suppresses Brain Aging” in Molecules (26:4897).

Dr. Unno’s research has garnered attention in the academic community, as evidenced by her recent publications and the awards she has received for her work. Her contributions continue to advance the understanding of dietary impacts on brain health and aging.

Conclusion

Dr. Unno’s contributions to her field are marked by a dedication to advancing knowledge through rigorous research and a focus on the practical applications of her findings. Her continued work promises to provide valuable insights into the complex interactions between diet, stress, and brain health.

Publications Top Notes

  • “Stress Reduction Potential in Mice Ingesting DNA from Salmon Milt”
  • “Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models”
  • “Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption”
    • Journal: International Journal of Molecular Sciences
    • Publication Date: March 27, 2023
    • DOI: 10.3390/ijms24076278
  • “Theanine, a Tea-Leaf-Specific Amino Acid, Alleviates Stress through Modulation of Npas4 Expression in Group-Housed Older Mice”
    • Journal: International Journal of Molecular Sciences
    • Publication Date: February 16, 2023
    • DOI: 10.3390/ijms24043983
  • “Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity”

 

 

Prof. Salvatore De-Simone | Diagnostic | Best Researcher Award

Prof. Salvatore De-Simone | Diagnostic | Best Researcher Award

The individual holds a degree in Biological Sciences (Medical Modality) from the State University of Rio de Janeiro, with further qualifications including a master’s and Ph.D. in Biochemistry from the Federal University of Rio de Janeiro, and Postdoctoral studies at New York University and the European Molecular Biology Laboratory (EMBL). They have served as a Professor of Biochemistry at the Federal Fluminense University and as Head of the Laboratory of Protein and Peptide Biochemistry at the Oswaldo Cruz Institute. Currently, they specialize in Science, Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS) and are a Scientist of Our State (FAPERJ) and a researcher at CNPq. Their research focuses on Biochemistry and Immunology, particularly in the biotechnology of infectious and parasitic agents. They work on defining the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for human and animal health. They are involved in the development and improvement of (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Their group has contributed to determining the complete or partial epitopes of various viruses, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Bank. They have also developed inputs and diagnostic methodologies for various pathologies.

Professional Profiles:

🎓 Education

Ph.D. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1981-1986. M.Sc. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1978-1980. B.Sc. in Biological Sciences (Medical Modality), State University of Rio de Janeiro, Brazil, 1973-1976. Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Germany, 1990. Postdoctoral Fellow, New York University, USA, 1988-1989. Postdoctoral Fellow, Hayem Center, St. Louis Hospital, France, 1988

🔬 Professional Experience

Specialist in Science & Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS), Brazil, 2012-present. Scientist of Our State (FAPERJ), Brazil. Researcher, CNPq, Brazil. Professor of Biochemistry, Universidade Federal Fluminense, Brazil. Head of the Laboratory of Protein and Peptide Biochemistry, Instituto Oswaldo Cruz, Brazil

💼 Other Positions and Activities

Member of the National Network of Experts in Zika and Related Diseases (RENEZIKA), Brazil. Member of the Rio Health Network (FAPERJ), Brazil. Member of the Integrated Chagas Disease Program and National Institute of Science and Technology in Neglected Diseases (INCT-IDPN), Brazil. Editorial Board Member of 2 international journals. Reviewer for over 90 scientific journals

🏆 Achievements

Defined the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for Human and animal Health. Developed and improved (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Determined the complete or partial epitopes of various viruses, including COVID-19, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Database (Immune Epitope Database and Analysis Resource (NIAID) of the National Institute of Health, USA). Developed diagnostic inputs and methodologies for various pathologies

Publications:

  1. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
    • Authors: V De Rosa, M Galgani, A Porcellini, A Colamatteo, M Santopaolo, …
    • Year: 2015
    • Citations: 338
  2. Occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil
    • Authors: VEP Martins, CH Alencar, MT Kamimura, FM de Carvalho Araujo, …
    • Year: 2012
    • Citations: 191
  3. Acinetobacter baumannii Infections in Times of COVID-19 Pandemic
    • Authors: K Rangel, TPG Chagas, SG De-Simone
    • Year: 2021
    • Citations: 122
  4. Isolation and partial characterization of a novel lectin from Talisia esculenta seeds that interferes with fungal growth
    • Authors: MF Maria das Graças, VM Gomes, RE Corsini, OLT Machado, …
    • Year: 2002
    • Citations: 106
  5. Partial purification and characterization of digestive trypsin-like proteases from the velvet bean caterpillar, Anticarsia gemmatalis
    • Authors: MGA Oliveira, SG De Simone, LP Xavier, RNC Guedes
    • Year: 2005
    • Citations: 96
  6. Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling
    • Authors: M Galgani, V De Rosa, S De Simone, A Leonardi, U D’Oro, G Napolitani, …
    • Year: 2004
    • Citations: 61
  7. B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3α (PvMSP-3α) in malaria exposed individuals from …
    • Authors: JC Lima-Junior, J Jiang, RN Rodrigues-da-Silva, DM Banic, TM Tran, …
    • Year: 2011
    • Citations: 59
  8. Immunome and venome of Bothrops jararacussu: a proteomic approach to study the molecular immunology of snake toxins
    • Authors: C Correa-Netto, R Teixeira-Araujo, AS Aguiar, AR Melgarejo, …
    • Year: 2010
    • Citations: 56
  9. Oligopeptidase B from L. amazonensis: molecular cloning, gene expression analysis and molecular model
    • Authors: HL de Matos Guedes, MPD Carneiro, DCO Gomes, B Rossi-Bergmanmn, …
    • Year: 2007
    • Citations: 55
  10. Characterization of an extracellular serine protease of Leishmania (Leishmania) amazonensis
    • Authors: RE Da Silva-Lopez, MGP Coelho, SG De Simone
    • Year: 2005
    • Citations: 54