Mrinal Ghosh | Cancer Biology | Best Researcher Award

Prof. Mrinal Ghosh | Cancer Biology | Best Researcher Award

Chief Scientist at CSIR-Indian Institute of Chemical Biology, India

Dr. Mrinal K. Ghosh is a distinguished Chief Scientist at the CSIR-Indian Institute of Chemical Biology and a Professor at AcSIR, New Delhi. With a Ph.D. in Biochemistry from the University of Calcutta, Dr. Ghosh specializes in cancer biology and inflammatory disorders. His extensive career includes leadership roles at CSIR-IICB and significant contributions to cancer research, particularly in glioma and breast cancer therapies. He has secured substantial funding for projects focusing on novel nanotechnology-based treatments and peptide therapeutics. Dr. Ghosh’s work has earned him prestigious awards such as the Bharat Vikash Award and recognition as a Fellow of the National Academy of Science & Technology. He is an active member of various scientific societies and has a robust publication record in high-impact journals. His research integrates advanced molecular biology techniques and translational medicine to address critical challenges in oncology.

Profile

Education

Dr. Mrinal K. Ghosh completed his education with a strong foundation in biochemistry and molecular biology. He earned his Ph.D. in Biochemistry from the University of Calcutta, India, where he conducted extensive research in the field from 1991 to 1997. Prior to his doctoral studies, Dr. Ghosh obtained his Master of Science degree in Biochemistry, with a focus on Molecular Biology, from the same institution in 1990. His undergraduate studies were in Chemistry, with honors, complemented by Physics and Mathematics, also at the University of Calcutta, culminating in his Bachelor of Science degree in 1988. Dr. Ghosh’s academic journey laid a solid groundwork for his subsequent research and leadership roles in cancer biology and inflammatory disorders, significantly contributing to his reputation as a leading scientist in his field.

Professional Experience

Dr. Mrinal K. Ghosh is a distinguished scientist with a remarkable career in cancer biology and inflammatory disorders. Currently serving as the Chief Scientist and Head of the Cancer Biology & Inflammatory Disorder Division at CSIR-Indian Institute of Chemical Biology (CSIR-IICB), he has been instrumental in advancing research in these fields. Prior to this role, he held positions as Senior Principal Scientist and Principal Scientist at CSIR-IICB, showcasing a trajectory of increasing responsibility. His earlier career included roles as Senior Lecturer at the Department of Biotechnology, HIT, Kolkata, and research positions at the Cleveland Clinic Foundation in the USA. Dr. Ghoshā€™s extensive experience includes leading significant research projects, managing research teams, and contributing to scientific advancements through his various roles and memberships in professional societies. His career is marked by his dedication to translating scientific discoveries into therapeutic innovations.

Research Interest

Dr. Mrinal K. Ghoshā€™s research interests focus on advancing cancer biology and inflammatory disorders through innovative biochemical and molecular approaches. His work emphasizes understanding the molecular mechanisms underlying cancer progression, particularly in glioma and breast cancer. Dr. Ghosh investigates the roles of key proteins and signaling pathways, including the p53 and Rb tumor suppressor proteins, and the ubiquitin-proteasome system in regulating cancer cell behavior. His research integrates nanotechnology and peptide therapeutics to develop novel treatment strategies, aiming to enhance the effectiveness of current therapies and overcome resistance. Additionally, Dr. Ghosh explores the implications of cancer biology in the context of stem cell research and neurodegenerative diseases. His comprehensive approach combines preclinical validation, clinical insights, and cutting-edge technology to address critical challenges in cancer treatment and provide new avenues for therapeutic interventions.

Research Skills

Dr. Mrinal K. Ghosh demonstrates exceptional research skills in the field of cancer biology and inflammatory disorders. His expertise spans molecular and cellular mechanisms, particularly in signal transduction related to cancer and stem cells. Dr. Ghosh is proficient in advanced techniques such as nanotechnology-based therapeutic systems, biomolecular target identification, and peptide therapeutic design. His research includes pre-clinical validation of therapies, focusing on glioma and breast cancer, utilizing sophisticated methods like protein modification and nanoparticle-based delivery systems. Dr. Ghosh’s ability to lead large-scale, multi-disciplinary projects is evident from his successful management of significant research grants and collaborations. His extensive publication record in high-impact journals and his role as a reviewer for leading scientific journals highlight his critical analytical skills and contribution to the scientific community. His innovative approach and comprehensive understanding of cancer biology underscore his research prowess.

Award and Recognition

Dr. Mrinal K. Ghosh has garnered significant recognition for his pioneering research in cancer biology and inflammatory disorders. His contributions have been acknowledged through numerous prestigious awards, including the Bharat Vikash Award in 2019, which honors outstanding achievements in scientific research. Dr. Ghosh is also a Fellow of the National Academy of Science & Technology (FNASc) and the Academy of Science & Technology (FAScT), reflecting his esteemed status within the scientific community. His research excellence is further underscored by his role as the Principal Investigator in several high-impact projects, such as the PAN-CSIR Cancer Research initiative and various DST-Nano Mission projects. Additionally, Dr. Ghosh has been honored with the Outstanding Scientist Award on Strategic Management and Business Strategy in 2023. These accolades, coupled with his extensive contributions to scientific literature and research, solidify his standing as a leading figure in his field.

Conclusion

Dr. Mrinal K. Ghosh is highly deserving of the Best Researcher Award due to his outstanding contributions to cancer biology and inflammatory disorders, as evidenced by his awards, extensive research funding, and high-impact publications. His leadership roles and recognition in the scientific community further underscore his excellence. Addressing areas such as enhancing international collaborations and increasing public engagement could further amplify his impact and align with broader scientific and societal goals.

Publications Top Notes

  1. MGMT in TMZ-based Glioma therapy: Multifaceted Insights and Clinical Trial Perspectives
    • Authors: Shaw R, Basu M, Karmakar S, Ghosh MK*
    • Journal: BBA – Molecular Cell Research
    • Year: 2024
    • Volume and Issue: 1871, 119673
    • Impact Factor: 5.1
    • Citations: 0
  2. Chromosomal instability (CIN) triggers immune evasion and metastatic potential in cancer through rewired STING signalling
    • Authors: Ghosh MK*, Roy S
    • Journal: Molecular Biomedicine
    • Year: 2024
    • Volume and Issue: 5(4)
    • Impact Factor: 6.0
    • Citations: 0
  3. E3 Ubiquitin Ligases in Lung Cancer: Emerging Insights and Therapeutic Opportunities
    • Authors: Basu B, Kal S, Karmakar S, Basu M, Ghosh MK*
    • Journal: Life Sciences
    • Year: 2024
    • Volume and Issue: 336, 122333
    • Impact Factor: 6.1
    • Citations: 0
  4. Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives
    • Authors: Kumar S#, Ansari A#, Basu M#, Ghosh S#, Begam S#, Ghosh MK#*
    • Journal: Advanced Therapeutics
    • Year: 2024
    • Impact Factor: 4.6
    • Citations: 0
    • Status: In press
  5. E3 ubiquitin ligases and deubiquitinases in colorectal cancer: Emerging molecular insights and therapeutic opportunities
    • Authors: Kumar S, Basu M, Ghosh MK*
    • Journal: BBA – Molecular Cell Research
    • Year: 2024
    • Volume and Issue: 1871, 119673
    • Impact Factor: 5.1
    • Citations: 0
    • Status: In press
  6. Glioma Immunotherapy: Exploring Molecular and Clinical Frontiers
    • Authors: Ghosh MK*, Kumar S, Begam S, Ghosh S, Basu M
    • Journal: Life Sciences
    • Year: 2024
    • Impact Factor: 5.2
    • Citations: 0
    • Status: In press
  7. Glioma nanotherapy: Unleashing the synergy of dual-loaded DIM and TMZ
    • Authors: Sarkar S#, Kumar S#, Saha G, Basu M, Ghosh MK*
    • Journal: International Journal of Pharmaceutics
    • Year: 2024
    • Impact Factor: 5.3
    • Citations: 0
    • Status: Under Review (R1)
  8. Unraveling COVID-19 diagnostics: A roadmap for future pandemic
    • Authors: Kumar S, Basu M*, Chakraborty D, Ghosh P, Bajoria S, Ghosh MK*
    • Journal: Nature Cell & Sciences
    • Year: 2024
    • Status: Under Review

2023 Publications:

  1. USP7 – A crucial regulator of Cancer Hallmarks
    • Authors: Saha G, Roy S, Basu M, Ghosh MK*
    • Journal: BBA ā€“ Reviews on Cancer
    • Year: 2023
    • Volume and Issue: 1878, 188903
    • Impact Factor: 11.2
    • Citations: 10
  2. Neurological damages in COVID-19 patients: mechanisms and preventive interventions
    • Authors: Sarkar S#, Karmakar S#, Basu M, Ghosh P, Ghosh MK*
    • Journal: MedComm
    • Year: 2023
    • Volume and Issue: 4, e247,1-25
    • Impact Factor: 10.7
    • Citations: 10