Professor at East china university of science & technology, China
Professor Meijin Guo is a renowned scholar in the field of bioengineering, currently serving as a full professor at the School of Bioengineering, East China University of Science and Technology (ECUST). With over two decades of academic and research experience, she has made significant contributions to microbial fermentation, stem cell bioprocessing, and metabolic regulation. Professor Guo holds a Ph.D. in Biochemical Engineering from ECUST, a Master’s degree in Microbiology from Guizhou University, and a Bachelor’s degree in Agronomy from Jiangxi Agricultural University. Her research has been instrumental in advancing technologies related to the large-scale production of mesenchymal stem cells, as well as in understanding the metabolic mechanisms of microbial synthesis under stress conditions. As a leading figure in national scientific projects, she has played key roles in high-impact studies supported by the National Natural Science Foundation of China and the Chinese Academy of Sciences. Professor Guo has authored numerous influential papers and serves as a co-corresponding author on multiple internationally recognized publications. Her work has also earned her prestigious national and provincial awards in scientific advancement. She is deeply committed to integrating engineering principles with biotechnology to solve real-world problems, bridge academic research and industrial applications, and foster innovation in biosciences.
Professional Profile
Education
Meijin Guo’s academic foundation reflects a strong interdisciplinary background that underpins her distinguished research career in bioengineering. She earned her Ph.D. in Biochemical Engineering from East China University of Science and Technology (1998–2001), where she began specializing in microbial metabolism and fermentation technologies. Her doctoral research laid the groundwork for her later contributions to bioreactor design and metabolic regulation. Prior to that, she obtained a Master’s degree in Microbiology from Guizhou University (1995–1998), focusing on microbial physiology and enzyme production. This period shaped her understanding of the biological and functional diversity of microorganisms, which remains central to her work. She started her academic journey with a Bachelor’s degree in Agronomy from Jiangxi Agricultural University (1988–1992), where she gained a solid grasp of plant and soil sciences, giving her early insight into life sciences from an agricultural perspective. Her seamless transition across agronomy, microbiology, and biochemical engineering highlights her multidisciplinary approach and commitment to addressing challenges across the life science spectrum. With this broad educational foundation, Professor Guo has cultivated a research style that bridges fundamental biology and practical engineering solutions, making her uniquely positioned to lead innovative research projects in the rapidly evolving field of biological engineering.
Professional Experience
Professor Meijin Guo has built a robust professional career centered on academic research and biotechnological innovation. She currently holds a professorship in the School of Bioengineering at East China University of Science and Technology (ECUST), a role she has occupied since October 2010. In this position, she leads multiple research projects, mentors graduate students, and contributes to academic development within the institution. Prior to this role, she served as an associate professor at ECUST from November 2005 to September 2010, furthering her work in fermentation optimization and bioreactor engineering. Between October 2004 and October 2005, she expanded her academic horizons with a research stint at the University of Strathclyde in the United Kingdom, where she engaged in international collaboration and broadened her scientific perspectives. From July 2001 to September 2004, she worked as an assistant researcher at the Biotechnology Center of Jiangxi Agricultural University, initiating her professional research journey with a focus on microbial technology and fermentation systems. Throughout her career, Professor Guo has consistently demonstrated a commitment to translating scientific knowledge into scalable biotechnological applications, earning respect in academic and industry circles alike. Her diverse experience underscores her capabilities as a leader in bioengineering and applied life sciences.
Research Interest
Professor Meijin Guo’s research interests lie at the intersection of microbial biotechnology, biochemical engineering, and stem cell bioprocessing. Her work primarily focuses on the development and scale-up of bioreactors for the mass production of stem cells, with a particular emphasis on mesenchymal stem cells derived from human embryonic and umbilical cord sources. She is passionate about optimizing bioreactor environments to preserve stem cell activity and function while enabling reproducibility at industrial scales. Another major aspect of her research involves exploring the stress-induced metabolic regulation of microbial systems, especially in vitamin B12 biosynthesis by Pseudomonas denitrificans under oxygen-limited conditions. Her research integrates omics technologies and computational modeling, including computational fluid dynamics, to understand and control bioprocess variables. Additionally, she has shown a keen interest in bioprocess parameter optimization, cell metabolism, and organoid-based toxicity screening platforms. This interdisciplinary approach allows her to develop innovative solutions for therapeutic applications and industrial biotechnology. Through collaboration with clinicians and bioengineers, she aims to bridge the gap between laboratory research and clinical or commercial implementation. Her ongoing projects reflect her commitment to applying systems biology and process engineering tools to improve biomanufacturing practices and advance personalized medicine through scalable and efficient bioprocesses.
Research Skills
Professor Meijin Guo brings an exceptional suite of research skills that reflect her deep engagement with modern bioengineering methodologies. She is highly experienced in bioreactor design and scale-up, with specific expertise in stirred suspension systems for stem cell culture. Her ability to integrate computational fluid dynamics (CFD) modeling into bioprocess development enables predictive design and real-time optimization of large-scale cell cultures. She is also proficient in microbial metabolic engineering, particularly for vitamin B12 biosynthesis under stress conditions, leveraging molecular biology tools to dissect and manipulate key biosynthetic pathways. In addition, she employs high-throughput screening technologies and label-free imaging platforms for compound toxicity studies using organoids, demonstrating her strength in cutting-edge cellular analysis techniques. Professor Guo also excels in experimental planning, data analysis, and scientific communication, often serving as co-corresponding author on high-impact journal publications. She is adept at leading multidisciplinary research teams and managing complex, large-scale projects funded by national and institutional grants. Her collaborative mindset and technical versatility enable her to adapt to rapidly evolving research challenges and contribute meaningfully to both fundamental research and translational applications. Through her skills, she not only drives scientific discovery but also enhances the reproducibility and scalability of biotechnological processes.
Awards and Honors
Professor Meijin Guo has received numerous prestigious awards in recognition of her scientific contributions to biochemical engineering and biotechnology. In 2002, she was part of a research team that won the State Scientific and Technological Progress Award (Second Class) from the State Council of China for their work on parameter-driven optimization and scale-up techniques in fermentation bioreactors. She was again honored in 2011 with another Second-Class National Award for Scientific and Technological Progress, recognizing her work in developing fermentation optimization technologies based on physiological and process information analysis. These accolades underscore her leadership in bridging theoretical and practical aspects of bioprocess engineering. Additionally, in 2003, she received a First-Class Provincial and Ministerial Science and Technology Progress Award from the Shanghai Municipal Government for her contributions to the production of thermostable phytase enzymes and gene identification related to high-activity phytase, highlighting her role in enzyme biotechnology. These awards, granted at both national and regional levels, reflect her sustained impact in the scientific community and her capacity to drive innovation in applied life sciences. Professor Guo’s honors not only recognize past achievements but also affirm her ongoing role as a pioneer in the field of biological engineering in China.
Conclusion
Professor Meijin Guo stands as a leading figure in China’s bioengineering landscape, with a career that combines scientific depth, technical innovation, and a collaborative spirit. Her academic journey from agronomy to microbiology and biochemical engineering has shaped a uniquely interdisciplinary research profile. Over the years, she has played a key role in advancing scalable bioprocessing systems, metabolic regulation studies, and the integration of computational modeling with experimental biology. Her extensive publication record and multiple research grants—both national and institutional—demonstrate her status as a trusted and capable leader in scientific inquiry. Through her work on stem cell bioreactors and vitamin biosynthesis, she has made critical contributions to biomanufacturing and therapeutic development. The national recognition she has received, including two prestigious State Scientific and Technological Progress Awards, affirms the real-world impact of her research. As science and technology continue to evolve, Professor Guo remains committed to mentoring young researchers, fostering cross-disciplinary partnerships, and applying engineering principles to solve complex biological challenges. Her continued leadership ensures that the bridge between scientific research and industrial innovation remains strong, timely, and impactful. In every aspect of her professional life, she embodies the values of rigor, creativity, and purpose-driven science.
Publications Top Notes
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Title: De Novo synthesis of selenium-doped CeO2@Fe3O4 nanoparticles for improving secondary metabolite biosynthesis in Carthamus tinctorius cell suspension culture
Authors: K. Ashraf, Z. Liu, Q.U. Zaman, … M. Guo, A. Mohsin
Year: 2025
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Title: Scalable Matrigel-Free Suspension Culture for Generating High-Quality Human Liver Ductal Organoids
Authors: S. Gong, K. He, … Z. Yang, M. Guo
Year: 2025
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Title: Temporal dynamics of stress response in Halomonas elongata to NaCl shock: physiological, metabolomic, and transcriptomic insights
Authors: J. Yu, Y. Zhang, H. Liu, … M. Guo, Z. Wang
Year: 2024
Citations: 7
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Title: Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity
Authors: B. Wang, G. Zhang, Y. Hu, … M. Guo, H. Xu
Year: 2024
Citations: 4
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Title: Sustainable biosynthesis of lycopene by using evolutionary adaptive recombinant Escherichia coli from orange peel waste
Authors: M. H. Hussain, S. Sajid, M. Martuscelli, … M. Guo, A. Mohsin
Year: 2024
Citations: 2
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Title: A novel perspective on the role of long non-coding RNAs in regulating polyphenols biosynthesis in methyl jasmonate-treated Siraitia grosvenorii suspension cells
Authors: Z. Liu, M. Guo (Meihui), A. Mohsin, … Z. Wang, M. Guo (Meijin)
Year: 2024
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Title: A machine learning-based approach for improving plasmid DNA production in Escherichia coli fed-batch fermentations
Authors: Z. Xu, X. Zhu, A. Mohsin, … M. Guo, G. Wang
Year: 2024
Citations: 3
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Title: Uncovering the Role of Hydroxycinnamoyl Transferase in Boosting Chlorogenic Acid Accumulation in Carthamus tinctorius Cells under Methyl Jasmonate Elicitation
Authors: Z. Liu, X. Zhu, A. Mohsin, … Y. Zhuang, M. Guo
Year: 2024
Citations: 2
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Title: Research on the Transient Expression of a Novel PCV2 Capsid Fusion Protein in HEK293F Cells
Authors: Q. Luo, Y. Peng, M. Ali (Mohsin), Y. Zhuang, M. Guo
Year: 2024
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Title: Polyphenol oxidase inhibition by Saccharomyces cerevisiae extracts: A promising approach to prevent enzymatic browning
Authors: Z. Liu, H. Ding, M. Martuscelli, … M. Guo, Z. Wang
Year: 2024
Citations: 5