Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

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Dr. Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

Professor at University of Virginia, United States

Dr. Lian-Wang Guo is a Professor of Biomedical Sciences at the University of Virginia with over 20 years of experience in vascular biology and biochemistry. His research primarily focuses on the role of epigenetic modulators in vascular diseases, particularly neointima-associated restenosis. He has been continuously funded by the NIH since 2012 and has published 48 peer-reviewed papers in the past six years, while also filing six patent applications. Dr. Guo’s innovative work includes developing biomimetic nanoplatforms for targeted drug delivery, which are currently in advanced trials for treating vascular conditions. His research integrates basic science with clinical applications, notably through collaboration with Dr. Craig Kent. Dr. Guo is recognized for his significant contributions to vascular epigenetics and has created a rigorous and inclusive training environment for young researchers. His work holds promise for advancing therapeutic strategies and improving clinical outcomes for vascular diseases.

Professional Profile

Education

Dr. Lian-Wang Guo’s educational background is rooted in biology and advanced plant physiology, providing a strong foundation for his extensive research career. He earned his Bachelor of Science degree in Biology from Xinjiang University in China in 1989, followed by a Master of Science in Plant Physiology from the prestigious Chinese Academy of Sciences in 1992. He continued his studies there, earning a Ph.D. in Plant Physiology and Biochemistry in 1995. Driven by a passion for genetics and biochemistry, Dr. Guo completed a postdoctoral fellowship at The Hebrew University of Jerusalem in 1998, where he broadened his research expertise in molecular biology. His educational journey reflects a commitment to understanding complex biological processes, which he has successfully applied to his pioneering work in vascular biology and epigenetics. Dr. Guo’s solid academic training has been instrumental in his innovative research contributions and leadership in biomedical sciences.

Professional Experience

Dr. Lian-Wang Guo is a tenured Professor of Biomedical Sciences at the University of Virginia, specializing in vascular biology and epigenetics. With over 20 years of research experience, Dr. Guo has developed an expertise in chromatin modulators and their role in vascular diseases, particularly in neointima-associated restenosis. He has been continuously funded by the NIH since 2012, and his prolific contributions include 48 peer-reviewed publications and multiple patents, reflecting his leadership in vascular epigenetics research. His laboratory employs advanced molecular techniques such as ChIPseq, RNAseq, bioinformatics, and innovative nanoplatforms for targeted drug delivery. Dr. Guo has also successfully fostered clinical collaborations, including the development of therapeutic interventions currently undergoing large animal trials, with preparations for human studies. A dedicated mentor, he has cultivated a rigorous training environment for students and fellows, helping them transition into independent research careers. His research has garnered numerous awards and recognition from prominent scientific organizations.

Research Interests

Lian-Wang Guo’s research interests center around the intersection of vascular biology, epigenetics, and targeted drug delivery. As a professor of Biomedical Sciences, his work focuses on understanding the role of chromatin modulators, such as EZH2, DOT1L, and BRD4, in vascular diseases, particularly neointima-associated restenosis. By uncovering how these epigenetic regulators influence disease-specific gene expression, he aims to develop precise therapeutic strategies that mitigate pathological vascular remodeling while preserving normal cellular functions. Dr. Guo is also deeply involved in translational research, advancing the use of biomimetic nanoplatforms for targeted, localized drug delivery. His lab has developed innovative nanotechnologies to deliver therapeutic agents to disease sites, aiming to enhance efficacy and minimize side effects. A key element of his research is the integration of basic science discoveries with clinical applications, as evidenced by his collaborations on vascular disease treatments currently in advanced stages of preclinical testing.

Lian-Wang Guo, Professor of Biomedical Sciences at the University of Virginia, has earned numerous prestigious awards and honors throughout his distinguished career. In 1996, he received the Award of Excellent Sci/Tech Articles from the Chinese Society of Plant Physiology. He has also been recognized with the University of Wisconsin-Madison Eye Research Institute Rapid Response Initiative Award (2008), the Morgridge Institute for Research Award (2014), and the New Investigator Award from the State of Wisconsin Partnership Program (2014). At The Ohio State University, he earned the Accelerator Award for Translation (2017). His editorial contributions include serving as Lead Guest Editor for Genes and Associate Editor for Frontiers in Cardiovascular Medicine. In 2023, he was elected as a Fellow of the American Heart Association (FAHA), and his outstanding research earned him recognition at the 2023 Research Achievement event at the University of Virginia, marking him as a leading figure in vascular biology and biomedical research.

Dr. Lian-Wang Guo’s extensive research contributions, particularly in vascular biology and epigenetics, position him as a leading scholar in biomedical sciences. His innovative work on chromatin modulators, specifically targeting epigenetic players like BRD4, EZH2, and DOT1L, has brought new insights into the treatment of neointimal-associated vascular diseases. Additionally, his development of nano-based, targeted drug delivery systems has shown promising translational potential, bridging the gap between basic science and clinical applications. With over 20 years of experience, numerous high-impact publications, NIH funding, and significant patents, Dr. Guo’s work is both cutting-edge and impactful. His mentorship of the next generation of scientists, as well as his collaborations with leading clinicians, further enhance his academic profile. While his contributions are already significant, a continued focus on clinical translation could maximize the impact of his research. Overall, Dr. Guo exemplifies the qualities of an outstanding researcher deserving of recognition.

 

Publication top noted
  • Article: Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression
    Authors: Li, J., Shen, H., Guo, L.-W.
    Year: 2024
    Citations: 0
  • Article: miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4
    Authors: Xie, X., Shirasu, T., Li, J., Guo, L.-W., Kent, K.C.
    Year: 2023
    Citations: 3
  • Article: Neointima abating and endothelium preserving — An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L
    Authors: Shirasu, T., Yodsanit, N., Li, J., Gong, S., Guo, L.-W.
    Year: 2023
    Citations: 1
  • Article: Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms
    Authors: Yodsanit, N., Shirasu, T., Huang, Y., Gong, S., Wang, B.
    Year: 2023
    Citations: 2
  • Article: Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation
    Authors: Zhang, M., Li, J., Wang, Q., Miller, C.L., Guo, L.-W.
    Year: 2023
    Citations: 3
  • Article: Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists
    Authors: Li, J., Satyshur, K.A., Guo, L.-W., Ruoho, A.E.
    Year: 2023
    Citations: 3
  • Article: Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
    Authors: Mavlyutov, T.A., Li, J., Liu, X., Pattnaik, B., Guo, L.-W.
    Year: 2022
    Citations: 4
  • Erratum: Correction: miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction (Cell Death Discovery, (2021), 7, 1, (318), 10.1038/s41420-021-00720-9)
    Authors: Xie, X., Guo, L.-W., Kent, C.K.
    Year: 2022
    Citations: 0
  • Article: Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
    Authors: Li, J., Félix-Soriano, E., Wright, K.R., Stanford, K.I., Guo, L.-W.
    Year: 2022
    Citations: 5
  • Article: SREBP1 regulates Lgals3 activation in response to cholesterol loading
    Authors: Li, J., Shen, H., Owens, G.K., Guo, L.-W.
    Year: 2022
    Citations: 9

Hayati Türkmen | Genetics and Molecular Biology | Best Researcher Award

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Prof. Hayati Türkmen | Genetics and Molecular Biology | Best Researcher Award 

Turkiye of Ege University, Turkey.

Prof. Dr. Hayati Türkmen is a distinguished academic in the field of inorganic chemistry, specializing in coordination chemistry, metal carbene complexes, catalysis, and boron chemistry. With a solid educational background, including a Ph.D. from Ege University, he has made significant contributions to the field through his extensive research and publications. His research interests span inorganic and organometallic chemistry, health sciences, and novel ligands. Dr. Türkmen has published over 100 papers and has received substantial citations, reflecting his influence in the scientific community. He has held various academic and administrative roles at Ege University, including Vice Dean and Director of Vocational School. His teaching portfolio includes advanced courses in inorganic chemistry and catalysis. Dr. Türkmen’s leadership in research and education, combined with his extensive publications and contributions to the field, highlight his eligibility for the Best Researcher Award.

Profile
Education

Dr. Hayati Türkmen completed his undergraduate studies in Chemistry at Karadeniz Technical University, Turkey, from 1993 to 1997. He then pursued a Master’s degree in Chemistry at Muğla Sıtkı Koçman University, graduating in 2000. Dr. Türkmen continued his academic journey by earning a Doctorate in Chemistry from Ege University, Turkey, between 2000 and 2007. His doctoral research focused on inorganic chemistry, which laid the foundation for his expertise in coordination chemistry, metal carbene complexes, and catalysis. This comprehensive educational background has equipped Dr. Türkmen with a solid foundation in both theoretical and applied chemistry, significantly contributing to his successful academic and research career in the field of inorganic and organometallic chemistry.

Professional Experience

Prof. Dr. Hayati Türkmen has a distinguished career in the field of chemistry, with extensive experience in both academia and administration. He has served as a Professor in the Department of Inorganic Chemistry at Ege University from 2015 to 2022, following his promotion from Associate Professor and Assistant Professor roles within the same department. His academic journey began with a role as a Research Assistant at Muğla Sıtkı Koçman University and Ege University, where he conducted significant research in coordination chemistry and catalysis. Prof. Türkmen has held several key administrative positions, including Vice Dean of the Faculty of Science at Ege University since 2022 and Director of Aliağa Vocational Training School from 2021 to 2022. His leadership extends to roles such as Head of Department at Ege University’s Graduate School of Natural and Applied Sciences and Rectorate Commissioner.

Research Interest

Dr. Hayati Türkmen’s research interests span several key areas within inorganic chemistry, including coordination chemistry, metal carbene complexes, and catalysis. His work focuses on the synthesis and application of novel ligands and metal-organic frameworks, aiming to develop advanced catalysts for industrial and environmental processes. Dr. Türkmen is particularly interested in boron chemistry and organometallic chemistry, exploring the potential of boron-based compounds in various chemical transformations. His research also extends to health sciences, where he investigates the role of metal complexes in biomedical applications. By integrating these diverse fields, Dr. Türkmen strives to advance fundamental understanding and practical applications of inorganic materials. His contributions to the development of new catalytic systems and materials have significant implications for both scientific research and industrial practice, highlighting his commitment to advancing the frontiers of chemistry and materials science.

Research Skills

Prof. Dr. Hayati Türkmen exhibits exceptional research skills across several domains of chemistry. His expertise spans coordination chemistry, metal carbene complexes, catalysis, and boron chemistry, reflecting a strong command over complex chemical systems and reactions. Dr. Türkmen is proficient in the development and application of novel ligands and metal-organic frameworks, which underpin his contributions to both fundamental research and practical applications in inorganic and organometallic chemistry. His research is characterized by meticulous experimental design and rigorous data analysis, as evidenced by his substantial publication record and citation metrics. Dr. Türkmen’s ability to synthesize new compounds and explore their catalytic properties demonstrates his innovative approach to solving chemical problems. His proficiency in mentoring graduate students and leading research projects further highlights his commitment to advancing the field through collaborative and high-impact research initiatives.

 Awards and Recognition

Dr. Hayati Türkmen has garnered significant recognition throughout his distinguished career in chemistry. His contributions to the field have been acknowledged with numerous accolades, reflecting his impact on research and education. Notably, he received the Ege University Research Award in 2021 for his outstanding achievements in inorganic chemistry and catalysis. In 2018, he was honored with the Excellence in Research Award by the Turkish Chemical Society, recognizing his innovative work in metal carbene complexes and boron chemistry. Additionally, Dr. Türkmen’s contributions to academic excellence were celebrated when he was awarded the Faculty Teaching Excellence Award in 2016, highlighting his dedication to education and mentorship. His ongoing influence and leadership in the scientific community are further evidenced by his active role in international research collaborations and editorial boards, cementing his reputation as a leading figure in his field.

Conclusion

Prof. Dr. Hayati Türkmen appears to be a strong candidate for the Research for Best Researcher Award. His extensive research output, significant citations, and leadership roles reflect a high level of accomplishment and influence in his field. Addressing areas for improvement, such as increasing citation impact and focusing research, could further strengthen his application. Overall, his achievements and contributions to science make him a compelling nominee for this prestigious award.

Publications Top Notes

  1. Efficient Synthesis of Novel 1,10 Phenanthroline-Substituted Imidazolium Salts: Exploring Their Anticancer Applications
    • Authors: Çakır, S., Ilhan, S., Atmaca, H., Türkmen, H.
    • Year: 2024
  2. Comparison of Ru(II)‒Arene Complexes Containing Naphthyl-/Quinolinyl-Substituted Ligand Vis-a-Vis Structure, Spectra and Catalytic Activity
    • Authors: Türkmen, G., Çakır, S., Batıkan Kavukcu, S., Şahin, O., Türkmen, H.
    • Year: 2024
    • Citations: 1
  3. Synthesis of Aryl-Functionalized Benzo[d,e]Benzo[4,5]Imidazo[2,1-a]Isoquinolin-7-One Derivatives: DNA Intercalation Causing Cytotoxicity
    • Authors: Türkmen, G., Çakır, S., Batıkan Kavukcu, S., Türkmen, H.
    • Year: 2024
  4. Synthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalation
    • Authors: Karabıyık, H., Karaer Tunçay, A., Ilhan, S., Atmaca, H., Türkmen, H.
    • Year: 2024
  5. Ruthenium Compounds: Are They the Next-Era Anticancer Agents?
    • Authors: Kavukcu, S.B., Özverel, C.S., Kıyak, N., Vatansever, H.S., Türkmen, H.
    • Year: 2024
  6. Anticancer Effect Evaluation of Nitron Complexes
    • Authors: Tolga Özdemir, V., Batıkan Kavukcu, S., Dila Çağlar, A., Nalbantsoy, A., Türkmen, H.
    • Year: 2024
  7. Cell Death Mechanism of Organometallic Ruthenium(II) and Iridium(III) Arene Complexes on HepG2 and Vero Cells
    • Authors: Kavukcu, S.B., Ensarioğlu, H.K., Karabıyık, H., Vatansever, H.S., Türkmen, H.
    • Year: 2023
    • Citations: 3
  8. N-Alkylation and N-Methylation of Amines with Alcohols Catalyzed by Nitrile-Substituted NHC-Ir(III) and NHC-Ru(II) Complexes
    • Authors: Çakır, S., Kavukcu, S.B., Şahin, O., Günnaz, S., Türkmen, H.
    • Year: 2023
    • Citations: 11
  9. Utilization of Various Solid Leather Wastes for the Production of Blended Bricks
    • Authors: Senthil, R., Kavukcu, S.B., Çakır, S., Başaran, B., Alagumuthu, T.
    • Year: 2022
    • Citations: 10
  10. Eco-Friendly Bioenergy: New Approaches for the Effective Treatment of Tannery Fleshings
    • Authors: Rethinam, S., Aruni, A.W., Türkmen, H.
    • Year: 2021
    • Citations: 3