Dr. Paul Cullen | Genetics | Best Researcher Award
Doctorate at University at Buffalo, United States
Dr. Paul Cullen is a Professor in the Department of Biological Sciences at the University at Buffalo, specializing in molecular genetics and cell biology. He completed his postdoctoral training at the Institute of Molecular Biology at the University of Oregon, where he worked on MAP kinase (MAPK) signaling pathways, funded by grants from the American Heart Association and the National Institutes of Health (NIH). Dr. Cullen earned his Ph.D. in Molecular Genetics from Washington University in Saint Louis, where his research focused on bacterial nitrogen control proteins. He holds a Bachelor of Science in Biological Sciences from the University of Illinois at Urbana-Champaign, graduating Magna Cum Laude with Distinction. Dr. Cullen’s research interests revolve around understanding the regulation of cellular differentiation and signaling pathways, particularly in yeast. He has received numerous accolades, including the UB Exceptional Scholar’s Award and the Distinguished Postdoc Mentor Award. His work is supported by multiple NIH grants, and he has contributed significantly to the scientific community through publications and mentorship.
Education
Dr. Paul Cullen holds an impressive educational background in the field of biological sciences and molecular genetics. He earned his Bachelor of Science degree in Biological Sciences from the University of Illinois, Urbana-Champaign, graduating Magna Cum Laude with Distinction in 1990. His undergraduate thesis, titled “Effect of Ecdysone on In Vitro Pupal Wing Development in Lepidoptera,” was conducted under the supervision of Dr. Judith Willis and Dr. Johnathan Widom. Following this, Dr. Cullen pursued his Doctor of Philosophy (Ph.D.) in Molecular Genetics at Washington University, Saint Louis, completing his degree in 1997. His Ph.D. research, titled “Bacterial Nitrogen Control Proteins,” was guided by Dr. Robert G. Kranz. Additionally, from 1998 to 2004, Dr. Cullen completed postdoctoral training at the Institute of Molecular Biology at the University of Oregon, under the mentorship of Dr. George F. Sprague, Jr. His postdoctoral work was supported by prestigious grants from the American Heart Association and the National Institutes of Health (NIH), further solidifying his expertise in molecular biology.
Dr. Paul Cullen has held a series of prestigious academic and research positions throughout his career. He is currently a Professor in the Department of Biological Sciences at the University at Buffalo, where he has been a faculty member since 2004. Prior to his promotion to Professor in 2017, Dr. Cullen served as an Associate Professor from 2010 to 2017 and as an Assistant Professor from 2004 to 2010. He has also held a joint appointment as Clinical Research Assistant Professor in the Department of Microbiology and Immunology since 2005. Earlier in his career, Dr. Cullen was a Senior Research Fellow at the Institute of Molecular Biology at the University of Oregon from 2000 to 2004. He has also contributed to scientific review panels, including serving as an NIH Review Panelist for Eukaryotic Pathogens in 2024. In addition to his research, Dr. Cullen has been deeply involved in academic administration, serving as the Director of Graduate Affairs for the Department of Biological Sciences from 2019 to 2024 and as a member of the Graduate School Executive Committee from 2023 to 2024.
Research Interest
Dr. Paul Cullen’s research interests focus on understanding the molecular mechanisms that regulate cellular differentiation, particularly through MAP kinase (MAPK) signaling pathways. His work explores how these pathways control cellular responses to environmental cues, with a special emphasis on the filamentous growth of Saccharomyces cerevisiae (yeast). Dr. Cullen investigates the role of cell polarity proteins in modulating MAPK signaling and how regulatory proteins influence these pathways. His research also extends to studying signal transduction in various biological systems, aiming to uncover broader implications for cellular behavior and development in eukaryotic organisms. Through his work, Dr. Cullen seeks to advance knowledge of genetic and molecular processes that underpin complex biological responses, contributing to the fields of molecular genetics, cell biology, and microbiology.
Dr. Paul Cullen possesses extensive research skills in molecular genetics and cell biology, particularly in the regulation of MAP kinase (MAPK) signaling pathways. His expertise includes advanced molecular techniques such as gene manipulation, protein-protein interaction studies, and genetic screening in model organisms like Saccharomyces cerevisiae. Dr. Cullen is skilled in using molecular and genetic tools to investigate cellular differentiation, signal transduction, and environmental response mechanisms. He has a strong background in high-throughput screening, microscopy, and quantitative data analysis. His research also involves cutting-edge technologies in genetic sequencing, bioinformatics, and structural biology, contributing to his deep understanding of cellular signaling networks and their implications for health and disease.
Dr. Paul Cullen has received numerous accolades for his exemplary contributions to research and education. In 2023, he was honored with the UB Exceptional Scholar’s Award for Sustained Achievement and the UB Graduate School Distinguished Postdoc Mentor Award, recognizing his significant impact in mentorship. Additionally, he received the Milton Plesur Excellence in Teaching Award in 2008 for his dedication to student learning. His active membership in professional organizations such as the American Society of Cell Biology and the American Society of Microbiology further highlights his commitment to advancing the field of molecular biology.
Dr. Paul Cullen’s remarkable achievements in molecular biology, sustained research contributions, and commitment to mentoring make him a distinguished figure in his field. His combination of academic excellence, leadership, and impactful research positions him as an exemplary candidate for the “Research for Best Researcher Award.”
Publication Top Notes
- “Glucose depletion causes haploid invasive growth in yeast”
- Journal: Proceedings of the National Academy of Sciences
- Cited by: 444
- Year: 2000
- Volume: 97, Issue 25
- Pages: 13619-13624
- “The regulation of filamentous growth in yeast”
- Journal: Genetics
- Cited by: 348
- Year: 2012
- Volume: 190, Issue 1
- Pages: 23-49
- “A signaling mucin at the head of the Cdc42-and MAPK-dependent filamentous growth pathway in yeast”
- Journal: Genes & Development
- Cited by: 268
- Year: 2004
- Volume: 18, Issue 14
- Pages: 1695-1708
- “GTPase-activating proteins for Cdc42”
- Journal: Eukaryotic Cell
- Cited by: 170
- Year: 2002
- Volume: 1, Issue 3
- Pages: 469-480
- “Defects in Protein Glycosylation Cause SHO1-Dependent Activation of a STE12 Signaling Pathway in Yeast”
- Journal: Genetics
- Cited by: 147
- Year: 2000
- Volume: 155, Issue 3
- Pages: 1005-1018
- “Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast”
- Journal: The Journal of Cell Biology
- Cited by: 144
- Year: 2008
- Volume: 181, Issue 7
- Pages: 1073-1081
- “Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis”
- Journal: PLoS One
- Cited by: 112
- Year: 2012
- Volume: 7, Issue 11
- Pages: e46020
- “Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins”
- Journal: NPJ Biofilms and Microbiomes
- Cited by: 111
- Year: 2019
- Volume: 5, Issue 1
- Pages: 21