Bo Li | Pharmaceutical Science | Best Researcher Award

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Prof. Dr. Bo Li | Pharmaceutical Science | Best Researcher Award

Researcher at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

Dr. Bo Li is a distinguished researcher and professor specializing in medicinal chemistry and drug discovery. He currently serves as a professor and MS supervisor at the Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, and the University of Chinese Academy of Sciences. Dr. Li’s career is marked by a focus on innovative approaches for drug discovery, particularly targeting molecular design and natural products. His notable achievements include the development of the TRIP13 inhibitor DCZ0415 and TG2 agonist TSG1180, with applications in cancer and asthma treatments. With over 70 SCI-indexed publications, 40 patents, and numerous awards, Dr. Li has made significant contributions to his field. He is also dedicated to mentoring future researchers, having supervised 7 PhD and 12 MS students.

Professional Profile

Education

Dr. Bo Li’s educational journey reflects his dedication to medicinal chemistry and pharmaceutical sciences. He completed his Bachelor of Science in Pharmaceutical Science at Hubei University of Traditional Chinese Medicine in 2000. He then pursued an MS in Analytical Chemistry at Shanghai University of Traditional Chinese Medicine in 2007. Dr. Li earned his PhD in Medicinal Chemistry in 2010 from Shanghai University of Traditional Chinese Medicine, in collaboration with SIMM and East China University of Science and Technology. Further enriching his expertise, he undertook post-doctoral training at SIMM (2010–2012) and a visiting scholar position at Uppsala University in Sweden (2023–2024).

Professional Experience

Dr. Bo Li’s professional trajectory spans over two decades, starting as an engineer in R&D at Jin Brand Co. Ltd. from 2000 to 2004. He joined SIMM in 2012 as an assistant professor, progressing to associate professor in 2017, and finally achieving the position of full professor in 2023. Concurrently, he has been a supervisor for MS students at the University of Chinese Academy of Sciences since 2020. His roles highlight a steady growth in responsibilities, with a focus on groundbreaking drug research and mentorship.

Research Interest

Dr. Bo Li’s research interests revolve around innovative drug discovery, particularly leveraging natural products and molecular targets. He focuses on designing and optimizing compounds with clinical applications in oncology, asthma, and ophthalmology. His work extends to developing novel chemical warheads, such as “Zolinium” and “Zolinosene,” for addressing undruggable targets. Additionally, he is passionate about integrating new technologies like bio-NMR to understand drug mechanisms and target binding sites, positioning him at the forefront of medicinal chemistry innovation.

Research Skills

Dr. Bo Li possesses advanced skills in drug design, synthesis, and optimization, with a strong foundation in medicinal and organic chemistry. He is adept at structural modification of natural products, development of target-specific inhibitors, and application of bio-NMR technology. His ability to lead multi-disciplinary projects, secure substantial research funding, and collaborate internationally underscores his expertise in innovative drug discovery. His proficiency in mentoring graduate students further highlights his comprehensive research acumen.

Awards and Honors

Dr. Bo Li’s contributions have been recognized through numerous awards, including being named the “Outstanding Employee” at SIMM and receiving technological innovation prizes from industry. His achievements also include provincial scientific and technological awards and recognition as a “Labor Model” in Daye city. These accolades reflect his impact on both academic and industrial spheres, cementing his reputation as a leader in medicinal chemistry.

Conclusion

Dr. Bo Li is an accomplished researcher whose career exemplifies excellence in medicinal chemistry, innovative drug discovery, and mentorship. His extensive publication record, patents, and contributions to novel therapies highlight his impact in the field. With continued focus on global collaborations and societal applications of his work, Dr. Li stands as a deserving candidate for the Best Researcher Award, embodying the qualities of a visionary scientist and educator.

Publication Top Notes

  1. Title: Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads
    Authors: Dong, S., Huang, H., Li, J., Li, B., Zhu, W.
    Year: 2024
  2. Title: Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma
    Authors: Li, X., Zhang, H., Dong, S., Shi, J., Zhu, W.
    Year: 2024
  3. Title: Corrigendum to “Berberine derivative DCZ0358 induced oxidative damage by ROS-mediated JNK signaling in DLBCL cells”
    Authors: Feng, Q., Hu, K., Hu, H., Zhu, W., Shi, J.
    Year: 2024
  4. Title: Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors
    Authors: Wei, Y., Xiong, Y., Liao, Q., Zhu, W., Ge, G.
    Year: 2024
  5. Title: Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma
    Authors: Chen, G., Gao, X., Jia, X., Zhu, W., Shi, J.
    Year: 2024
    Citations: 6
  6. Title: Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents
    Authors: Wang, J., Zhou, C., Li, B., Zhang, H., Liu, L.
    Year: 2024
  7. Title: Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma
    Authors: Lai, Y., Guo, S., Tang, Q., Zhu, W., Shi, J.
    Year: 2024
  8. Title: A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory
    Authors: Zhang, H., Hu, K., Lu, Y., Zhu, W., Shi, J.
    Year: 2024
  9. Title: Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity in vitro and in vivo
    Authors: Dong, S., Hu, K., Shi, Y., Shi, J., Zhu, W.
    Year: 2024
    Citations: 4
  10. Title: The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
    Authors: Wang, Y., Dong, S., Hu, K., Zhu, W., Shi, J.
    Year: 2023
    Citations: 4

 

Muhammad Usama Mazhar | Pharmaceutical Science | Best Researcher Award

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Mr. Muhammad Usama Mazhar | Pharmaceutical Science | Best Researcher Award

PhD scholar at Quaid-i-Azam university, Pakistan

Muhammad Usama Mazhar is a dedicated pharmacologist and educator with over 4 years of teaching experience in nursing, medicine, dentistry, and pharmacy. He has recently submitted his Ph.D. thesis in pharmacology at Quaid-i-Azam University, Islamabad, and his research focuses on immunopharmacology and toxicology, particularly the anti-inflammatory potential of probiotics. With nine research publications and a total impact factor of 19.2, his work has contributed significantly to understanding inflammation, arthritis, and neuroinflammation. He has been recognized for academic excellence, receiving multiple scholarships and the Best Teacher award at Yusra Institute of Pharmaceutical Sciences. Additionally, he has actively participated in conferences and workshops, demonstrating a commitment to continuous learning and professional growth. His technical skills include proficiency in software like SPSS, GraphPad Prism, and Image J. Muhammad Usama Mazhar is a motivated researcher with strong potential in his field.

Profile:

Education

Muhammad Usama Mazhar has a solid educational background in pharmacology. He is currently pursuing a Doctor of Philosophy (Ph.D.) in Pharmacology at Quaid-i-Azam University, Islamabad, with his thesis already submitted for foreign evaluation, marking a significant milestone in his academic journey. Prior to this, he completed his Master of Philosophy (M.Phil) in Pharmacology from Riphah International University, Islamabad, in 2017, achieving a commendable CGPA of 3.54/4. His academic foundation was laid with a Doctor of Pharmacy (Pharm.D.) from The University of Lahore, where he graduated in 2014 with an impressive CGPA of 3.73/4. Throughout his studies, Muhammad Usama Mazhar consistently demonstrated academic excellence, earning multiple scholarships and securing the 2nd position in his class on several occasions. His educational background showcases a strong focus on pharmacological research, which has been complemented by his professional and research experiences in the field.

Professional Experience

Muhammad Usama Mazhar has accumulated over four years of diverse professional experience, primarily in academia and the healthcare sector. He has served as a lecturer and lab instructor at prestigious institutions, including Quaid-i-Azam University and CMH Lahore Medical College, where he taught subjects like anatomy and pharmacology to students in nursing, medicine, dentistry, and pharmacy. His teaching experience is complemented by his administrative role as a warden at CMH Lahore Medical College, where he also contributed to promotional activities. Additionally, he worked as a pharmacist at Ali Medical Center and completed an internship at Quaid-e-Azam International Hospital, providing him with practical experience in clinical pharmacology. His roles have allowed him to merge academic teaching with practical healthcare skills, establishing a well-rounded career in pharmacology and pharmaceutical sciences.

Research Interest

Muhammad Usama Mazhar’s research interests primarily lie in immunopharmacology and toxicology, with a particular focus on the anti-inflammatory potential of probiotics and the pharmacological mechanisms of natural compounds. His work explores how probiotics like Bacillus subtilis can modulate immune responses and protect against inflammatory diseases, such as arthritis. He also investigates the toxicological effects of various agents and their potential therapeutic applications in combating inflammation and oxidative stress. Mazhar is keen on understanding the pharmacokinetics and safety profiles of these compounds, seeking to bridge the gap between natural remedies and clinical applications. His recent studies have delved into the neuroinflammatory pathways involved in stress-induced seizures and the anti-arthritic potential of Coagulansin-A, a compound with promising immunomodulatory properties. His research aims to contribute to the development of safer, more effective therapeutic agents for inflammatory and autoimmune diseases.

Research Skills

Muhammad Usama Mazhar possesses a diverse set of research skills, particularly in the fields of immunopharmacology and toxicology. His expertise spans experimental design, laboratory techniques, and data analysis, as demonstrated by his work on the anti-inflammatory potential of probiotics and the pharmacological evaluation of compounds such as Bacillus subtilis and Coagulansin-A. He has a strong command of statistical tools such as GraphPad Prism and SPSS, which he uses for complex data analysis and interpretation. Additionally, his proficiency in software like ImageJ for image processing further enhances his analytical capabilities. With nine peer-reviewed publications in high-impact journals, Usama has effectively conducted in vivo and in vitro studies, showcasing his ability to manage multifaceted research projects. His active participation in workshops and conferences demonstrates his commitment to staying updated on current trends in pharmacology and biomedical research, making him a well-rounded researcher in his field

Award and Recognitions

Muhammad Usama Mazhar has received notable awards and recognitions throughout his academic and professional career. During his Pharm.D. studies, he earned multiple scholarships for academic excellence, securing 2nd position in his class across several semesters and graduating 2nd in his batch with a CGPA of 3.73. His dedication to teaching was acknowledged with a Certificate of Appreciation from Yusra Institute of Pharmaceutical Sciences and recognition as the Best Teacher for the 2015-16 session. These accolades reflect his commitment to academic excellence and his impactful contributions as an educator. Additionally, his extensive research efforts have been recognized through publications in reputable journals, further solidifying his reputation in the field of pharmacology. These honors highlight his consistent performance, commitment to research, and significant contributions to both education and the scientific community.

Conclusion

Muhammad Usama Mazhar is a strong candidate for the Best Researcher Award, particularly due to his impressive publication record, teaching experience, and honors. Expanding his international collaborations and focusing on larger research projects could elevate his profile further. Given his recent Ph.D. submission and ongoing research, he is on a promising trajectory for future accolades in pharmacology.

Publication Top Notes