Prof. Salvatore De-Simone | Diagnostic | Best Researcher Award

Prof. Salvatore De-Simone | Diagnostic | Best Researcher Award

The individual holds a degree in Biological Sciences (Medical Modality) from the State University of Rio de Janeiro, with further qualifications including a master’s and Ph.D. in Biochemistry from the Federal University of Rio de Janeiro, and Postdoctoral studies at New York University and the European Molecular Biology Laboratory (EMBL). They have served as a Professor of Biochemistry at the Federal Fluminense University and as Head of the Laboratory of Protein and Peptide Biochemistry at the Oswaldo Cruz Institute. Currently, they specialize in Science, Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS) and are a Scientist of Our State (FAPERJ) and a researcher at CNPq. Their research focuses on Biochemistry and Immunology, particularly in the biotechnology of infectious and parasitic agents. They work on defining the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for human and animal health. They are involved in the development and improvement of (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Their group has contributed to determining the complete or partial epitopes of various viruses, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Bank. They have also developed inputs and diagnostic methodologies for various pathologies.

Professional Profiles:

🎓 Education

Ph.D. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1981-1986. M.Sc. in Biochemistry, Federal University of Rio de Janeiro, Brazil, 1978-1980. B.Sc. in Biological Sciences (Medical Modality), State University of Rio de Janeiro, Brazil, 1973-1976. Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL), Germany, 1990. Postdoctoral Fellow, New York University, USA, 1988-1989. Postdoctoral Fellow, Hayem Center, St. Louis Hospital, France, 1988

🔬 Professional Experience

Specialist in Science & Technology, Production, and Innovation in Public Health (FIOCRUZ/CDTS), Brazil, 2012-present. Scientist of Our State (FAPERJ), Brazil. Researcher, CNPq, Brazil. Professor of Biochemistry, Universidade Federal Fluminense, Brazil. Head of the Laboratory of Protein and Peptide Biochemistry, Instituto Oswaldo Cruz, Brazil

💼 Other Positions and Activities

Member of the National Network of Experts in Zika and Related Diseases (RENEZIKA), Brazil. Member of the Rio Health Network (FAPERJ), Brazil. Member of the Integrated Chagas Disease Program and National Institute of Science and Technology in Neglected Diseases (INCT-IDPN), Brazil. Editorial Board Member of 2 international journals. Reviewer for over 90 scientific journals

🏆 Achievements

Defined the biological, immunological, and biochemical bases of diagnostic and therapeutic targets for Human and animal Health. Developed and improved (bio)materials, (nano)products, and biological and biotechnological processes for industrial and agricultural production. Determined the complete or partial epitopes of various viruses, including COVID-19, bacteria, and other infectious and parasitic agents, with deposits in the International Epitope Database (Immune Epitope Database and Analysis Resource (NIAID) of the National Institute of Health, USA). Developed diagnostic inputs and methodologies for various pathologies

Publications:

  1. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
    • Authors: V De Rosa, M Galgani, A Porcellini, A Colamatteo, M Santopaolo, …
    • Year: 2015
    • Citations: 338
  2. Occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil
    • Authors: VEP Martins, CH Alencar, MT Kamimura, FM de Carvalho Araujo, …
    • Year: 2012
    • Citations: 191
  3. Acinetobacter baumannii Infections in Times of COVID-19 Pandemic
    • Authors: K Rangel, TPG Chagas, SG De-Simone
    • Year: 2021
    • Citations: 122
  4. Isolation and partial characterization of a novel lectin from Talisia esculenta seeds that interferes with fungal growth
    • Authors: MF Maria das Graças, VM Gomes, RE Corsini, OLT Machado, …
    • Year: 2002
    • Citations: 106
  5. Partial purification and characterization of digestive trypsin-like proteases from the velvet bean caterpillar, Anticarsia gemmatalis
    • Authors: MGA Oliveira, SG De Simone, LP Xavier, RNC Guedes
    • Year: 2005
    • Citations: 96
  6. Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling
    • Authors: M Galgani, V De Rosa, S De Simone, A Leonardi, U D’Oro, G Napolitani, …
    • Year: 2004
    • Citations: 61
  7. B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3α (PvMSP-3α) in malaria exposed individuals from …
    • Authors: JC Lima-Junior, J Jiang, RN Rodrigues-da-Silva, DM Banic, TM Tran, …
    • Year: 2011
    • Citations: 59
  8. Immunome and venome of Bothrops jararacussu: a proteomic approach to study the molecular immunology of snake toxins
    • Authors: C Correa-Netto, R Teixeira-Araujo, AS Aguiar, AR Melgarejo, …
    • Year: 2010
    • Citations: 56
  9. Oligopeptidase B from L. amazonensis: molecular cloning, gene expression analysis and molecular model
    • Authors: HL de Matos Guedes, MPD Carneiro, DCO Gomes, B Rossi-Bergmanmn, …
    • Year: 2007
    • Citations: 55
  10. Characterization of an extracellular serine protease of Leishmania (Leishmania) amazonensis
    • Authors: RE Da Silva-Lopez, MGP Coelho, SG De Simone
    • Year: 2005
    • Citations: 54

 

Mr. Sebastian Vacca | Neuroimaging

🎉🏆 Congratulations, Mr. Sebastian Vacca , on Your Outstanding Achievement as the Best Researcher! 🏆🎉
Mr. Sebastian Vacca : Leading Researcher in Social Work

Medical Student at Neuroimaging, Università degli Studi di Cagliari, Italy

Your remarkable academic journey, extensive research contributions, and dedication to the field of psychology are truly commendable. Your wealth of knowledge and diverse skill set reflect a deep commitment to understanding and addressing critical issues such as bullying, inclusion, and socialization.

🔬 Your successful completion of a PhD in Psychology, along with the numerous advanced courses and workshops, showcases your continuous pursuit of excellence and expertise in your field.

🏆 The awards and recognitions, including the First Place in the Poster Award at the University of Stavanger, underscore the impact of your research and the high regard it holds in the academic community.

Professional Profiles:

Research Collaborator at Mayo Clinic

At Mayo Clinic, I serve as a Research Collaborator, contributing to a focused Deep Learning Project aimed at enhancing the segmentation of brain tumors, with a particular emphasis on intracranial meningiomas. Under the guidance of Supervisor Gian Marco Conte, MD PhD, my role involves applying advanced techniques to improve the accuracy of brain tumor segmentation.

Research Assistant at Cagliari State University – Radiology Department

As a Research Assistant at Cagliari State University’s Radiology Department, I actively participate in multiple projects investigating radiological anomalies. Employing Statistical methods and Machine Learning models, I analyze clinical and imaging data from patients with neurologic lupus. Additionally, I lead efforts in conducting systematic reviews with meta-analysis, specifically focusing on the application of radiomics in carotid atherosclerotic disease. I am also involved in constructing a machine learning model based on radiomics and automated segmentation to predict atherosclerotic plaque at risk for stroke, working under the guidance of Professor Luca Saba, MD.

Scientific Collaborator at One Medic – The One Health Community

In my role as a Scientific Collaborator at One Medic, I am an active member of the Research and Podcast Team. I contributed to a Bibliometric study, exploring the most cited articles in the field of One Health. Additionally, I played a crucial role in organizing and supporting podcast activities, combining research insights with effective communication strategies.

Diverse Research and Academic Contributions

Research Trainee – International Journal of Clinical Research [ 03/2023 – 12/2023 ] As the Group Leader for a Neurology Research Working Group, I led a comprehensive review on treatment options for Multiple Sclerosis. This role allowed me to delve into the intricacies of neurological research, contributing valuable insights to the field.

Visiting Medical Student – Technische Universität München [ 01/09/2022 – 30/11/2022 ] During my tenure as a student researcher in the Functional Neuronavigation and Monitoring Working Group, I played a crucial role in analyzing clinical, DTI, and Tractography data from patients with a Corpus Callosum GBM. Responsible for data collection, I also contributed to CC segmentation using ITK-SNAP, tumor segmentation, Fiber-Tracking on BrainLab Elements, and performed statistical analysis under the guidance of Prof Dr. Med Sebastian Ille.

Publication

Title: SBM vs VBM for highlighting similarities and differences between Chronotype and Parkinson’s MRI scans: a preliminary analysis

Publication Date: 2023

Authors: Sebastiano Vacca, Jyoti Suri, Luca Saba

Journal: International Journal of Neuroscience