Prof. Saverio Cinti is a distinguished researcher and academic in the field of obesity, adipose tissue physiology, and human anatomy. With over 35 years of experience in medical research and education, he has made groundbreaking contributions to the understanding of fat biology, metabolism, and obesity-related disorders. He has served as a Full Professor of Human Anatomy at Marche Polytechnic University and is currently the Scientific Director of the Obesity Center at the same institution. His prolific research output includes over 340 peer-reviewed publications, with an impressive H-index of 87 and 37,585 citations (Scopus), demonstrating his global influence in the scientific community. He has also authored books, contributed to over 20 book chapters, and holds multiple patents in the field of metabolic diseases. Prof. Cinti has been an invited speaker at prestigious institutions, including Harvard, Columbia, NIH, and the European Congress of Endocrinology. His contributions have been recognized with prestigious awards, such as the Blaise Pascal Medal and the Friedrich Wassermann Prize. As a pioneer in adipose tissue research, his work continues to shape the future of obesity treatment and metabolic health on an international scale.
Professional Profile
Education
Prof. Saverio Cinti’s academic journey began with a Doctor of Medicine (MD) degree from the University of Padua in 1974. He then pursued specialization in Internal Medicine at the University of Verona (1979) and Surgical Pathology at the University of Milan (1982). His advanced training provided him with a strong foundation in human anatomy, cellular biology, and pathology, which later became central to his research on obesity and adipose tissue. Over the years, he has continuously expanded his expertise, engaging in multidisciplinary medical research and international collaborations. His education has been complemented by extensive teaching experience, particularly in anatomy, histology, and obesity-related metabolic studies. His deep understanding of human anatomy and pathology has allowed him to bridge the gap between basic research and clinical applications. His affiliation with global institutions, including the University of Copenhagen and the University of Bonn, further highlights his role as a leading educator and researcher in the field. His academic background, combined with his dedication to continuous learning, has positioned him as a key figure in obesity and metabolic disorder research.
Professional Experience
Prof. Cinti has held several prominent academic and research positions over the past four decades. From 1984 to 2020, he was the Head of the Anatomy and Cell Biology Unit at the Department of Experimental and Clinical Medicine at Marche Polytechnic University. He served as a Full Professor of Human Anatomy from 1986 to 2020, where he played a crucial role in shaping medical education. His leadership extends beyond academia, as he has also been the Director of the Obesity Center at Marche Polytechnic University since 2011 and the Scientific Director of the Obesity Center since 2020. His international experience includes being an Affiliated Professor at the University of Copenhagen and a Distinguished Professor Emeritus at the University of Bonn. Additionally, he has served as the President of the Italian Society of Obesity (SIO) from 2008 to 2010. His long-standing involvement in clinical research and academic leadership has significantly contributed to advancements in obesity and adipose tissue research. His career is marked by extensive grant funding (~€2.5 million), numerous high-impact publications, and collaborative efforts in obesity and metabolic disease research.
Research Interest
Prof. Cinti’s research primarily focuses on adipose tissue biology, obesity mechanisms, and metabolic disorders. His work has provided crucial insights into the function, differentiation, and plasticity of adipocytes, particularly in relation to metabolic diseases such as diabetes and obesity. He has extensively studied the role of white, brown, and beige adipose tissue in energy metabolism and thermogenesis. His research also explores the cellular and molecular mechanisms of fat storage, lipid metabolism, and the impact of obesity on systemic health. A key aspect of his work involves understanding how adipose tissue dysfunction contributes to metabolic syndrome, cardiovascular diseases, and inflammation-related disorders. He has been actively involved in translational research, bridging laboratory discoveries with potential clinical applications for obesity treatment. His studies on leptin, irisin, and adipose-derived stem cells have contributed to the development of innovative therapies for metabolic diseases. Additionally, his research extends to regenerative medicine, focusing on adipose tissue engineering for tissue repair and renewal. His contributions continue to shape obesity research, paving the way for novel therapeutic approaches and a better understanding of adipose tissue biology.
Research Skills
Prof. Cinti possesses a diverse range of research skills, making him a leading authority in obesity and adipose tissue studies. He is highly skilled in electron microscopy, histological analysis, and molecular biology techniques, which he has used to investigate the structure and function of adipose tissues. His expertise in cellular and molecular biology has allowed him to make groundbreaking discoveries regarding adipocyte differentiation and metabolic regulation. He is proficient in animal models of obesity, metabolic syndrome, and diabetes, enabling him to conduct preclinical research on obesity treatments. His work also involves biochemical assays, gene expression analysis, and imaging techniques to study fat metabolism and energy homeostasis. Additionally, he has experience in clinical research methodologies, including patient-based studies on obesity, metabolic disorders, and regenerative medicine. His strong background in scientific writing and peer reviewing has led to contributions in top-tier journals such as Nature, Science, and Cell Metabolism. His ability to integrate basic science with clinical applications has made him a pioneer in translational obesity research.
Awards and Honors
Prof. Cinti has received numerous prestigious awards in recognition of his contributions to obesity research. In 2008, he was awarded the Blaise Pascal Medal by the European Academy of Science, a prestigious honor for his pioneering work in metabolic diseases. In 2013, he received the Friedrich Wassermann Prize from the European Association for the Study of Obesity (EASO), further highlighting his impact on obesity research. He has also been honored as a Distinguished Professor Emeritus at the University of Bonn and has been a plenary speaker at international conferences, including Harvard, Columbia University, and the European Congress of Endocrinology. He has served as a peer reviewer for leading journals such as Science, Nature, and Cell Metabolism, further cementing his reputation as a global expert in obesity and metabolic disorders. His extensive contributions have also been recognized through significant research funding (~€2.5 million over the last decade) and multiple patents related to obesity treatment and metabolic health. These awards and honors reflect his exceptional influence in the scientific community.
Conclusion
Prof. Saverio Cinti is an internationally renowned researcher whose groundbreaking work in obesity and adipose tissue biology has significantly advanced the field. With an illustrious career spanning over four decades, he has contributed extensively through research, education, and leadership roles. His vast publication record, high citation impact, and numerous awards showcase his global influence. His research has led to new insights into fat metabolism, obesity treatment, and regenerative medicine, positioning him at the forefront of translational obesity research. His commitment to scientific excellence, combined with his mentorship and leadership roles, has inspired countless researchers worldwide. Moving forward, expanding interdisciplinary collaborations, integrating emerging technologies, and increasing public outreach could further enhance his already significant impact. Prof. Cinti’s contributions make him a strong candidate for the Best Researcher Award, reflecting his exceptional dedication to scientific progress and medical innovation.
Publications Top Notes
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Title: A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Authors: P. Boström, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, J.C. Lo, K.A. Rasbach, …
Year: 2012
Citations: 5879
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Title: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Authors: Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, …
Year: 1999
Citations: 4936
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Title: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Authors: S. Cinti, G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, …
Year: 2005
Citations: 3248
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Title: Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
Authors: R. Cancello, C. Henegar, N. Viguerie, S. Taleb, C. Poitou, C. Rouault, …
Year: 2005
Citations: 1498
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Title: Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Authors: P. Seale, H.M. Conroe, J. Estall, S. Kajimura, A. Frontini, J. Ishibashi, P. Cohen, …
Year: 2011
Citations: 1482
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Title: Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
Authors: J. Lin, P.H. Wu, P.T. Tarr, K.S. Lindenberg, J. St-Pierre, C. Zhang, V.K. Mootha, …
Year: 2004
Citations: 1465
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Title: The adipose organ
Authors: S. Cinti
Year: 2007
Citations: 1161
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Title: βAR signaling required for diet-induced thermogenesis and obesity resistance
Authors: E.S. Bachman, H. Dhillon, C.Y. Zhang, S. Cinti, A.C. Bianco, B.K. Kobilka, …
Year: 2002
Citations: 1079
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Title: Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
Authors: P. Cohen, J.D. Levy, Y. Zhang, A. Frontini, D.P. Kolodin, K.J. Svensson, J.C. Lo, …
Year: 2014
Citations: 967
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Title: The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
Authors: G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, K. Kristiansen, …
Year: 2010
Citations: 948
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Title: The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Authors: M.C. Zingaretti, F. Crosta, A. Vitali, M. Guerrieri, A. Frontini, B. Cannon, …
Year: 2009
Citations: 915
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Title: Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
Authors: I. Murano, G. Barbatelli, V. Parisani, C. Latini, G. Muzzonigro, M. Castellucci, …
Year: 2008
Citations: 879