Prof. Dr. Bo Li | Pharmaceutical Science | Best Researcher Award
Researcher at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
Dr. Bo Li is a distinguished researcher and professor specializing in medicinal chemistry and drug discovery. He currently serves as a professor and MS supervisor at the Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, and the University of Chinese Academy of Sciences. Dr. Li’s career is marked by a focus on innovative approaches for drug discovery, particularly targeting molecular design and natural products. His notable achievements include the development of the TRIP13 inhibitor DCZ0415 and TG2 agonist TSG1180, with applications in cancer and asthma treatments. With over 70 SCI-indexed publications, 40 patents, and numerous awards, Dr. Li has made significant contributions to his field. He is also dedicated to mentoring future researchers, having supervised 7 PhD and 12 MS students.
Professional Profile
Education
Dr. Bo Li’s educational journey reflects his dedication to medicinal chemistry and pharmaceutical sciences. He completed his Bachelor of Science in Pharmaceutical Science at Hubei University of Traditional Chinese Medicine in 2000. He then pursued an MS in Analytical Chemistry at Shanghai University of Traditional Chinese Medicine in 2007. Dr. Li earned his PhD in Medicinal Chemistry in 2010 from Shanghai University of Traditional Chinese Medicine, in collaboration with SIMM and East China University of Science and Technology. Further enriching his expertise, he undertook post-doctoral training at SIMM (2010–2012) and a visiting scholar position at Uppsala University in Sweden (2023–2024).
Professional Experience
Dr. Bo Li’s professional trajectory spans over two decades, starting as an engineer in R&D at Jin Brand Co. Ltd. from 2000 to 2004. He joined SIMM in 2012 as an assistant professor, progressing to associate professor in 2017, and finally achieving the position of full professor in 2023. Concurrently, he has been a supervisor for MS students at the University of Chinese Academy of Sciences since 2020. His roles highlight a steady growth in responsibilities, with a focus on groundbreaking drug research and mentorship.
Research Interest
Dr. Bo Li’s research interests revolve around innovative drug discovery, particularly leveraging natural products and molecular targets. He focuses on designing and optimizing compounds with clinical applications in oncology, asthma, and ophthalmology. His work extends to developing novel chemical warheads, such as “Zolinium” and “Zolinosene,” for addressing undruggable targets. Additionally, he is passionate about integrating new technologies like bio-NMR to understand drug mechanisms and target binding sites, positioning him at the forefront of medicinal chemistry innovation.
Research Skills
Dr. Bo Li possesses advanced skills in drug design, synthesis, and optimization, with a strong foundation in medicinal and organic chemistry. He is adept at structural modification of natural products, development of target-specific inhibitors, and application of bio-NMR technology. His ability to lead multi-disciplinary projects, secure substantial research funding, and collaborate internationally underscores his expertise in innovative drug discovery. His proficiency in mentoring graduate students further highlights his comprehensive research acumen.
Awards and Honors
Dr. Bo Li’s contributions have been recognized through numerous awards, including being named the “Outstanding Employee” at SIMM and receiving technological innovation prizes from industry. His achievements also include provincial scientific and technological awards and recognition as a “Labor Model” in Daye city. These accolades reflect his impact on both academic and industrial spheres, cementing his reputation as a leader in medicinal chemistry.
Conclusion
Dr. Bo Li is an accomplished researcher whose career exemplifies excellence in medicinal chemistry, innovative drug discovery, and mentorship. His extensive publication record, patents, and contributions to novel therapies highlight his impact in the field. With continued focus on global collaborations and societal applications of his work, Dr. Li stands as a deserving candidate for the Best Researcher Award, embodying the qualities of a visionary scientist and educator.
Publication Top Notes
- Title: Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads
Authors: Dong, S., Huang, H., Li, J., Li, B., Zhu, W.
Year: 2024 - Title: Design, synthesis, and biological evaluation of novel 1-amido-2-one-4-thio-deoxypyranose as potential antitumor agents for multiple myeloma
Authors: Li, X., Zhang, H., Dong, S., Shi, J., Zhu, W.
Year: 2024 - Title: Corrigendum to “Berberine derivative DCZ0358 induced oxidative damage by ROS-mediated JNK signaling in DLBCL cells”
Authors: Feng, Q., Hu, K., Hu, H., Zhu, W., Shi, J.
Year: 2024 - Title: Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors
Authors: Wei, Y., Xiong, Y., Liao, Q., Zhu, W., Ge, G.
Year: 2024 - Title: Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma
Authors: Chen, G., Gao, X., Jia, X., Zhu, W., Shi, J.
Year: 2024
Citations: 6 - Title: Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents
Authors: Wang, J., Zhou, C., Li, B., Zhang, H., Liu, L.
Year: 2024 - Title: Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma
Authors: Lai, Y., Guo, S., Tang, Q., Zhu, W., Shi, J.
Year: 2024 - Title: A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory
Authors: Zhang, H., Hu, K., Lu, Y., Zhu, W., Shi, J.
Year: 2024 - Title: Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity in vitro and in vivo
Authors: Dong, S., Hu, K., Shi, Y., Shi, J., Zhu, W.
Year: 2024
Citations: 4 - Title: The novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
Authors: Wang, Y., Dong, S., Hu, K., Zhu, W., Shi, J.
Year: 2023
Citations: 4