Xiuling Wang | Molecular Biology | Best Researcher Award

Dr. Xiuling Wang | Molecular Biology | Best Researcher Award

Department of Medical Laboratory from The Central Hospital of Wuhan, China

Xiuling Wang is a dedicated biomedical researcher and senior clinical laboratory professional currently serving as a Chief Technician at the Department of Laboratory Medicine, Wuhan Central Hospital, affiliated with Huazhong University of Science and Technology. With a doctoral degree in Pathogenic Biology from Wuhan University, she has consistently contributed to the field of immunology, particularly focusing on macrophage biology, neuroinflammation, and retroviral protein functions. Her publication record demonstrates a strong commitment to scientific advancement, with multiple articles featured in high-impact journals such as Metabolism, Immunology & Cell Biology, Archives of Virology, and Brain, Behavior and Immunity. While she has not held postdoctoral roles or national-level research grants, her independent research has made a significant impact in her specialized domain. She combines practical laboratory skills with theoretical insights to investigate inflammatory pathways and immune responses relevant to infectious and neurological diseases. Her work has implications in understanding immune regulation, epigenetics, and cellular signaling. With a balanced combination of laboratory practice and academic research, Xiuling Wang exemplifies the integration of clinical application with biomedical discovery. Her potential for future contributions remains high, especially if supported by expanded research funding and collaborative networks at national and international levels.

Professional Profile

Education

Xiuling Wang’s academic journey reflects a strong foundation in life sciences and biomedical research. She earned her Ph.D. in Pathogenic Biology from Wuhan University between September 2011 and December 2017. During her doctoral studies, she focused on understanding host-pathogen interactions and molecular mechanisms of immune regulation, which later shaped the core of her research interests. Her Ph.D. work laid the groundwork for exploring the functional roles of histone modification and endogenous retroviral proteins in inflammatory responses. Before pursuing her doctoral degree, she completed a Bachelor of Science in Biological Sciences at Shenyang Agricultural University from September 2007 to July 2011. This undergraduate program provided her with fundamental training in cellular biology, genetics, and microbiology. Her academic progression from a broad-based biological science education to a specialized doctoral study in pathogenic biology demonstrates a clear trajectory toward expertise in immunology and infectious disease research. Although she has not undertaken formal postdoctoral research, her doctoral education, combined with her clinical laboratory responsibilities, has enabled her to independently carry out impactful research. Her academic background continues to influence her scientific inquiry into macrophage activation, inflammatory signaling, and the epigenetic regulation of immune cells.

Professional Experience

Xiuling Wang has built her professional career primarily within Wuhan Central Hospital, affiliated with Huazhong University of Science and Technology, where she currently holds the role of Chief Technician in the Department of Laboratory Medicine. Since February 2020, she has been leading technical operations and contributing to both diagnostic and research activities in the clinical laboratory. Prior to this position, from December 2017 to January 2020, she served as a Technician in the same department. During these years, she has developed and refined her expertise in molecular diagnostics, cellular analysis, and immunological assays. Her clinical role complements her academic background, allowing her to bridge laboratory research with patient-centered diagnostics. Her work environment has enabled her to explore inflammatory responses, macrophage polarization, and immune regulation through both clinical samples and experimental models. Despite the lack of formal postdoctoral appointments or international placements, her responsibilities have encompassed advanced lab techniques, experiment design, and publication-driven research. She has proven her ability to produce high-quality scientific output independently, which speaks to her technical proficiency and analytical capability. Her career development within a university-affiliated hospital also highlights her commitment to integrating scientific inquiry into healthcare improvements.

Research Interests

Xiuling Wang’s research interests lie at the intersection of immunology, molecular biology, and virology, with a strong emphasis on inflammatory mechanisms and immune regulation. Her primary focus has been on the functional roles of endogenous retroviral proteins, histone modification enzymes, and transcription factors in mediating immune cell responses. She is particularly interested in how epigenetic regulators such as G9a and PCAF modulate macrophage polarization during lipid exposure and inflammation. Her investigations into proteins like Syncytin-1 and HERV-W env in glial cells further demonstrate her focus on neuroinflammation and innate immunity. These studies have direct implications for understanding the pathogenesis of neurodegenerative and autoimmune diseases. Additionally, her research seeks to elucidate the signaling cascades involving toll-like receptors (TLRs), MyD88, KLF2/4, and cytokine production in the central nervous system and peripheral immune tissues. Xiuling Wang is also interested in the translational application of these findings for diagnostics and therapeutic strategies. Her interdisciplinary interests span across disease biology, epigenetics, and immunopathology. By integrating experimental findings with clinical relevance, she aims to uncover novel mechanisms of immune dysfunction and offer potential biomarkers or targets for inflammatory diseases and neurological disorders.

Research Skills

Xiuling Wang possesses a wide array of research skills that make her proficient in conducting independent biomedical research. She has significant expertise in immunological techniques, including cytokine profiling, flow cytometry, and cell culture assays, which are critical for studying macrophage activity and inflammatory responses. Her experience also includes molecular biology techniques such as quantitative PCR, Western blotting, and RNA interference, allowing her to explore gene expression and protein regulation. She has used advanced imaging and immunohistochemistry tools in her analysis of glial cell activation. In addition, she is skilled in epigenetic assays that examine histone modifications and transcription factor interactions, essential to her investigations into G9a and PCAF functions. Xiuling has a strong foundation in virology, particularly involving endogenous retroviruses, which she integrates into neuroimmunology research. Her clinical role further equips her with real-world experience in sample handling, clinical diagnostics, and quality control procedures, bridging basic science with applied medicine. These capabilities have enabled her to produce high-quality research publications without extensive postdoctoral or institutional funding. Her technical self-sufficiency, combined with rigorous scientific thinking, positions her as a valuable contributor to the field of immunological research and molecular diagnostics.

Awards and Honors

As of now, Xiuling Wang has not received any formal academic awards, honors, or fellowships, nor has she been recognized through funded research grants such as those from the National Natural Science Foundation of China. Despite this, her scientific merit is evident through her publications in high-impact, peer-reviewed journals. Her work has been published in prestigious journals like Metabolism, Immunology & Cell Biology, Archives of Virology, and Brain, Behavior and Immunity, all of which require rigorous peer review and serve as a testament to her scholarly contributions. While institutional or national recognition remains an area for growth, her research output demonstrates academic independence, persistence, and relevance. She has navigated the competitive research landscape through individual effort and clinical integration, achieving visibility through her findings rather than through awards. This indicates that her contributions have been more organically driven by scientific inquiry than by external accolades. As her career continues, participating in professional societies, applying for national research funding, and engaging in collaborative projects could open opportunities for formal recognition. These steps would complement her existing academic foundation and further solidify her status in the biomedical research community.

Conclusion

Xiuling Wang exemplifies the qualities of a committed and capable biomedical researcher, blending clinical practice with rigorous academic investigation. With a doctoral degree in pathogenic biology and years of hands-on laboratory experience, she has carved a niche in understanding immune regulation and inflammatory pathways. Her work—particularly on macrophage polarization, endogenous retroviral proteins, and histone-modifying enzymes—has added valuable insight to the fields of immunology and neurobiology. While she has not yet led nationally funded projects or received major awards, her consistent publication record reflects both scientific competence and independence. She operates effectively in a clinical-academic environment, translating laboratory findings into contextually relevant insights. Her strengths lie in research depth, technical proficiency, and topic relevance. Future career development would benefit from expanded participation in funding applications, interdisciplinary collaborations, and recognition through academic awards or society memberships. Nonetheless, based on her publication impact and research quality, she stands as a strong candidate for the Best Researcher Award. Her potential for further contributions remains high, making her a valuable asset in the scientific exploration of immune mechanisms and inflammation-related diseases.

Publications Top Notes

  • Title: P300/CBP-associated factor (PCAF) attenuated M1 macrophage inflammatory responses possibly through KLF2 and KLF4

  • Journal: Immunology and Cell Biology

  • Year: 2021

  • Citations: 25

Mario D. Cordero | Molecular Biology | Best Researcher Award

Dr. Mario D. Cordero | Molecular Biology | Best Researcher Award

Principal Investigator at Pablo de Olavide University, Spain

Mario David Cordero Morales is a distinguished professional and researcher known for his contributions to [specific field/area of expertise]. With a robust academic foundation and a wealth of experience in both academia and industry, he has demonstrated an unwavering commitment to advancing knowledge and fostering innovation. His career is marked by interdisciplinary collaboration, a keen focus on applied research, and significant contributions to [specific applications or innovations]. A recipient of numerous accolades, Mario David is recognized as a leader who consistently bridges the gap between theoretical research and practical implementation.

Professional Profile

Education

Mario David Cordero Morales holds an extensive academic background that has laid the groundwork for his professional success. He earned his [degree] in [field] from [university], where he developed expertise in [key area]. Building on this, he pursued advanced studies, completing a [degree/doctorate] in [specific specialization] at [university], with a thesis focusing on [specific topic]. His educational journey also includes specialized training and certifications in [specific courses], ensuring his alignment with emerging trends and technologies.

Professional Experience

With [X years] of professional experience, Mario David has held pivotal roles in academia, research, and industry. As [current position] at [organization], he leads initiatives in [key responsibilities]. Previously, he contributed significantly as [previous roles] at [institutions/organizations], where he worked on groundbreaking projects like [specific projects]. His professional journey reflects a trajectory of increasing responsibility and influence, with a focus on [core professional themes].

Research Interests

Mario David’s research interests lie at the intersection of [fields], particularly focusing on [specific topics]. His work seeks to address critical challenges in [industry/area], leveraging [specific methodologies or technologies]. He has a strong passion for exploring [emerging topics], which has positioned him as a thought leader in [field]. Through collaboration with global researchers, Mario continues to pioneer advancements in [specific innovations].

Research Skills

Mario David is equipped with a diverse set of research skills that enhance his contributions to [field]. Proficient in [specific methodologies], he excels in [technical skills like data analysis, modeling, lab techniques]. His expertise in [tools/software] enables him to tackle complex research problems efficiently. He is adept at designing and managing large-scale projects, fostering interdisciplinary collaboration, and mentoring junior researchers to achieve excellence.

Awards and Honors

Mario David has received numerous accolades recognizing his excellence in research and professional contributions. Notable honors include [specific awards], which highlight his impact on [field]. He has also been awarded fellowships and grants from esteemed organizations like [specific institutions]. His dedication to [specific cause or innovation] has earned him accolades that underscore his status as a respected figure in [industry/field].

Conclusion

Mario David Cordero Morales is an exemplary researcher with a compelling journey and significant contributions to biomedical research. His work on inflammasomes and aging is both innovative and impactful, supported by an impressive publication record, international collaborations, and leadership in advancing knowledge in this field. While there is scope for diversification and industry engagement, his achievements, resilience, and scientific influence make him a strong contender for the Best Researcher Award.

Publication Top Notes

1.The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice

  • Authors: Muela-Zarzuela, I., Suarez-Rivero, J.M., Boy-Ruiz, D., Sanz, A., Cordero, M.D.
  • Year: 2024
  • Journal: Aging Cell
  • Volume and Issue: 23(9), e14272

2. Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?

  • Authors: Suarez-Rivero, J.M., López-Pérez, J., Astorga-Gamaza, A., Mazuecos, A., Cordero, M.D.
  • Year: 2024
  • Journal: Antioxidants and Redox Signaling
  • Volume and Issue: 41(7-9), pp. 479–487

3. NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

  • Authors: Muela-Zarzuela, I., Suarez-Rivero, J.M., Gallardo-Orihuela, A., Mbalaviele, G., Cordero, M.D.
  • Year: 2024
  • Journal: Inflammation Research
  • Volume and Issue: 73(8), pp. 1253–1266
  • Citations: 2

4. Does Donor Age Have Effects on Senescence Biomarkers in Kidney-Transplanted Patients?

  • Authors: López-Pérez, J., Suarez-Rivero, J.M., Muela-Zarzuela, I., Mazuecos, A., Cordero, M.D.
  • Year: 2024
  • Journal: Antioxidants and Redox Signaling
  • Volume and Issue: 40(13-15), pp. 751–758
  • Citations: 1

5. Modulatory effect of Andean blackberry polyphenols on genes related to antioxidant and inflammatory responses, the NLRP3 inflammasome, and autophagy

  • Authors: Castejón-Vega, B., Kyriakidis, N.C., Alcócer-Gómez, E., Cordero, M.D., Alvarez-Suarez, J.M.
  • Year: 2024
  • Journal: Journal of Berry Research
  • Volume and Issue: 14(1), pp. 41–59
  • Citations: 1

6. How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing

  • Authors: Castejon-Vega, B., Cordero, M.D., Sanz, A.
  • Year: 2023
  • Journal: Antioxidants
  • Volume and Issue: 12(4), 831
  • Citations: 8

7. L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation

  • Authors: Castejón-Vega, B., Rubio, A., Pérez-Pulido, A.J., Alcocer-Gómez, E., Cordero, M.D.
  • Year: 2021
  • Journal: Cells
  • Volume and Issue: 10(11), 3122
  • Citations: 3

8. Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria

  • Authors: González-Dominguez, A., Montañez, R., Castejón-Vega, B., Alcocer-Gómez, E., Cordero, M.D.
  • Year: 2021
  • Journal: EMBO Molecular Medicine
  • Volume and Issue: 13(10), e14012
  • Citations: 19

9. Glial cells (Book Chapter)

  • Authors: Williams, M., Macdonald, C., Cordero, M.D.
  • Year: 2021
  • Book: The Neuropathology of Schizophrenia
  • Pages: 221–241

10. Potential role of the mitochondria for the dermatological treatment of Papillon-Lefèvre

  • Authors: Castejón-Vega, B., Battino, M., Quiles, J.L., Cordero, M.D., Bullón, P.
  • Year: 2021
  • Journal: Antioxidants
  • Volume and Issue: 10(1), pp. 1–9, 95
  • Citations: 5

 

 

 

Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

Dr. Lian-Wang Guo | Genetics and Molecular Biology| Best Researcher Award

Professor at University of Virginia, United States

Dr. Lian-Wang Guo is a Professor of Biomedical Sciences at the University of Virginia with over 20 years of experience in vascular biology and biochemistry. His research primarily focuses on the role of epigenetic modulators in vascular diseases, particularly neointima-associated restenosis. He has been continuously funded by the NIH since 2012 and has published 48 peer-reviewed papers in the past six years, while also filing six patent applications. Dr. Guo’s innovative work includes developing biomimetic nanoplatforms for targeted drug delivery, which are currently in advanced trials for treating vascular conditions. His research integrates basic science with clinical applications, notably through collaboration with Dr. Craig Kent. Dr. Guo is recognized for his significant contributions to vascular epigenetics and has created a rigorous and inclusive training environment for young researchers. His work holds promise for advancing therapeutic strategies and improving clinical outcomes for vascular diseases.

Professional Profile

Education

Dr. Lian-Wang Guo’s educational background is rooted in biology and advanced plant physiology, providing a strong foundation for his extensive research career. He earned his Bachelor of Science degree in Biology from Xinjiang University in China in 1989, followed by a Master of Science in Plant Physiology from the prestigious Chinese Academy of Sciences in 1992. He continued his studies there, earning a Ph.D. in Plant Physiology and Biochemistry in 1995. Driven by a passion for genetics and biochemistry, Dr. Guo completed a postdoctoral fellowship at The Hebrew University of Jerusalem in 1998, where he broadened his research expertise in molecular biology. His educational journey reflects a commitment to understanding complex biological processes, which he has successfully applied to his pioneering work in vascular biology and epigenetics. Dr. Guo’s solid academic training has been instrumental in his innovative research contributions and leadership in biomedical sciences.

Professional Experience

Dr. Lian-Wang Guo is a tenured Professor of Biomedical Sciences at the University of Virginia, specializing in vascular biology and epigenetics. With over 20 years of research experience, Dr. Guo has developed an expertise in chromatin modulators and their role in vascular diseases, particularly in neointima-associated restenosis. He has been continuously funded by the NIH since 2012, and his prolific contributions include 48 peer-reviewed publications and multiple patents, reflecting his leadership in vascular epigenetics research. His laboratory employs advanced molecular techniques such as ChIPseq, RNAseq, bioinformatics, and innovative nanoplatforms for targeted drug delivery. Dr. Guo has also successfully fostered clinical collaborations, including the development of therapeutic interventions currently undergoing large animal trials, with preparations for human studies. A dedicated mentor, he has cultivated a rigorous training environment for students and fellows, helping them transition into independent research careers. His research has garnered numerous awards and recognition from prominent scientific organizations.

Research Interests

Lian-Wang Guo’s research interests center around the intersection of vascular biology, epigenetics, and targeted drug delivery. As a professor of Biomedical Sciences, his work focuses on understanding the role of chromatin modulators, such as EZH2, DOT1L, and BRD4, in vascular diseases, particularly neointima-associated restenosis. By uncovering how these epigenetic regulators influence disease-specific gene expression, he aims to develop precise therapeutic strategies that mitigate pathological vascular remodeling while preserving normal cellular functions. Dr. Guo is also deeply involved in translational research, advancing the use of biomimetic nanoplatforms for targeted, localized drug delivery. His lab has developed innovative nanotechnologies to deliver therapeutic agents to disease sites, aiming to enhance efficacy and minimize side effects. A key element of his research is the integration of basic science discoveries with clinical applications, as evidenced by his collaborations on vascular disease treatments currently in advanced stages of preclinical testing.

Lian-Wang Guo, Professor of Biomedical Sciences at the University of Virginia, has earned numerous prestigious awards and honors throughout his distinguished career. In 1996, he received the Award of Excellent Sci/Tech Articles from the Chinese Society of Plant Physiology. He has also been recognized with the University of Wisconsin-Madison Eye Research Institute Rapid Response Initiative Award (2008), the Morgridge Institute for Research Award (2014), and the New Investigator Award from the State of Wisconsin Partnership Program (2014). At The Ohio State University, he earned the Accelerator Award for Translation (2017). His editorial contributions include serving as Lead Guest Editor for Genes and Associate Editor for Frontiers in Cardiovascular Medicine. In 2023, he was elected as a Fellow of the American Heart Association (FAHA), and his outstanding research earned him recognition at the 2023 Research Achievement event at the University of Virginia, marking him as a leading figure in vascular biology and biomedical research.

Dr. Lian-Wang Guo’s extensive research contributions, particularly in vascular biology and epigenetics, position him as a leading scholar in biomedical sciences. His innovative work on chromatin modulators, specifically targeting epigenetic players like BRD4, EZH2, and DOT1L, has brought new insights into the treatment of neointimal-associated vascular diseases. Additionally, his development of nano-based, targeted drug delivery systems has shown promising translational potential, bridging the gap between basic science and clinical applications. With over 20 years of experience, numerous high-impact publications, NIH funding, and significant patents, Dr. Guo’s work is both cutting-edge and impactful. His mentorship of the next generation of scientists, as well as his collaborations with leading clinicians, further enhance his academic profile. While his contributions are already significant, a continued focus on clinical translation could maximize the impact of his research. Overall, Dr. Guo exemplifies the qualities of an outstanding researcher deserving of recognition.

 

Publication top noted
  • Article: Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression
    Authors: Li, J., Shen, H., Guo, L.-W.
    Year: 2024
    Citations: 0
  • Article: miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4
    Authors: Xie, X., Shirasu, T., Li, J., Guo, L.-W., Kent, K.C.
    Year: 2023
    Citations: 3
  • Article: Neointima abating and endothelium preserving — An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L
    Authors: Shirasu, T., Yodsanit, N., Li, J., Gong, S., Guo, L.-W.
    Year: 2023
    Citations: 1
  • Article: Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms
    Authors: Yodsanit, N., Shirasu, T., Huang, Y., Gong, S., Wang, B.
    Year: 2023
    Citations: 2
  • Article: Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation
    Authors: Zhang, M., Li, J., Wang, Q., Miller, C.L., Guo, L.-W.
    Year: 2023
    Citations: 3
  • Article: Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N’-Dimethylsphingosine Are Endogenous Agonists
    Authors: Li, J., Satyshur, K.A., Guo, L.-W., Ruoho, A.E.
    Year: 2023
    Citations: 3
  • Article: Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation
    Authors: Mavlyutov, T.A., Li, J., Liu, X., Pattnaik, B., Guo, L.-W.
    Year: 2022
    Citations: 4
  • Erratum: Correction: miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction (Cell Death Discovery, (2021), 7, 1, (318), 10.1038/s41420-021-00720-9)
    Authors: Xie, X., Guo, L.-W., Kent, C.K.
    Year: 2022
    Citations: 0
  • Article: Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
    Authors: Li, J., Félix-Soriano, E., Wright, K.R., Stanford, K.I., Guo, L.-W.
    Year: 2022
    Citations: 5
  • Article: SREBP1 regulates Lgals3 activation in response to cholesterol loading
    Authors: Li, J., Shen, H., Owens, G.K., Guo, L.-W.
    Year: 2022
    Citations: 9