Dr. Liton Kumar Saha | Cancer | Excellence in Research

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Dr. Liton Kumar Saha | Cancer | Excellence in Research

Post-doctoral Fellow at Cancer, National Cancer Institute, United States

👨‍🎓He remarkable academic journey, extensive research contributions, and dedication to the field of psychology are truly commendable. Your wealth of knowledge and diverse skill set reflect a deep commitment to understanding and addressing critical issues such as bullying, inclusion, and socialization.

🔬 He successful completion of a PhD in Psychology, along with the numerous advanced courses and workshops, showcases your continuous pursuit of excellence and expertise in your field.

🏆 The awards and recognitions, including the First Place in the Poster Award at the University of Stavanger, underscore the impact of your research and the high regard it holds in the academic community.

Professional Profiles:

Education/Research:

From July 2019 to the present, [Name] has served as a Postdoctoral Fellow (Visiting) at the Developmental Therapeutics Branch, National Cancer Institute, NIH. His research focuses on PARP1, TOP3A, Replication, DNA repair, DNA-protein crosslink, mitochondria, and related topics. He earned his Ph.D. degree in Medical Sciences from the Graduate School of Medicine, Kyoto University, Kyoto, Japan, from 2016 to 2019. His Ph.D. research was conducted in the Department of Radiation Genetics, where he investigated the novel function of genes in DNA repair and DNA damage tolerance. He achieved this by generating mutants in human cell lines using CRISPR/Cas9 and TALEN technology. Prior to his Ph.D., he completed his Master’s degree in medical sciences at the Graduate School of Medicine, Kyoto University, Kyoto, Japan, from 2014 to 2016. His research during this period focused on DNA repair and toxicology, specifically utilizing DNA-repair-deficient cells to identify genotoxins with greater sensitivity and characterizing DNA lesions caused by industrial chemical compounds. He received his Master’s degree in Biochemistry and Molecular Biology from the Faculty of Biological Sciences, University of Dhaka, Dhaka, Bangladesh, in 2007-2008. His dissertation was on the phenotypic and molecular characterization of Salmonella Typhi isolated recently in Bangladesh. He also holds a Bachelor’s degree in Biochemistry and Molecular Biology from the Faculty of Biological Sciences, University of Dhaka, Dhaka, Bangladesh, achieved with distinction, from 2001 to 2006.

🔬 Visiting Research Associate

  • Dr. Samuel H. Wilson lab
  • Genome Integrity and Structure Biology Laboratory
  • National Institute of Environmental Health Sciences (NIEHS), NIH, USA
  • March 2017-May 2017
  • Research Topic: Established In-vitro base excision repair (BER) of CPD lesion-containing DNA (cell-extract based and enzyme-mediated both).

🔬 Visiting Research Associate

  • Professor Ian D Hickson lab
  • Center for Chromosome Stability
  • Institute of Cellular and Molecular Medicine
  • Faculty of Health and Medical Sciences
  • University of Copenhagen, Copenhagen, Denmark
  • September 2015- November 2017
  • Research Topic: Performed and established the protocol for the detection of ultrafine DNA bridges (UFBs) in human TK6 cells using MRE11 mutant.

🔬 Research Assistant

  • Department of Radiation Genetics
  • Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • August 2013- March 2014

🔬 Research Officer

  • International Center for Diarrheal Diseases Research, Bangladesh (ICDDR, B)
  • Dhaka, Bangladesh
  • 2009-2012

Awards:

During the period of 2014 to 2019, [Name] was awarded a Scholarship from the Training Program of Leaders for Integrated Medical System: for Fruitful Healthy-Longevity Society in Japan. Additionally, in 2018, he received a research grant from the Training Program of Leaders for Integrated Medical System at Kyoto University, Japan. Similarly, in both 2017 and 2016, he was also awarded research grants from the same Training Program at Kyoto University, Japan.

Publications:

  1. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes
    • Authors: H Sasanuma, M Tsuda, S Morimoto, LK Saha, MM Rahman, Y Kiyooka, …
    • Citations: 81
    • Year: 2018
  2. Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)
    • Authors: Y Sun, S Saha, W Wang, LK Saha, SYN Huang, Y Pommier
    • Citations: 72
    • Year: 2020
  3. Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and enhances the chemotherapeutic activity of widely used DNA damaging agents
    • Authors: U Jo, IS Senatorov, A Zimmermann, LK Saha, Y Murai, SH Kim, …
    • Citations: 64
    • Year: 2021
  4. Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
    • Authors: Y Sun, LK Saha, S Saha, U Jo, Y Pommier
    • Citations: 56
    • Year: 2020
  5. SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
    • Authors: U Jo, Y Murai, S Chakka, L Chen, K Cheng, J Murai, LK Saha, …
    • Citations: 34
    • Year: 2021
  6. Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes
    • Authors: LK Saha, Y Murai, S Saha, U Jo, M Tsuda, S Takeda, Y Pommier
    • Citations: 22
    • Year: 2021
  7. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells
    • Authors: LK Saha, M Wakasugi, S Akter, R Prasad, SH Wilson, N Shimizu, …
    • Citations: 21
    • Year: 2020
  8. The ARK assay is a sensitive and versatile method for the global detection of DNA-protein crosslinks
    • Authors: Q Hu, N Klages-Mundt, R Wang, E Lynn, LK Saha, H Zhang, M Srivastava, …
    • Citations: 21
    • Year: 2020
  9. UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks
    • Authors: R Akagawa, HT Trinh, LK Saha, M Tsuda, K Hirota, S Yamada, A Shibata, …
    • Citations: 18
    • Year: 2020