Professor of Pathology, Director of Hematopathology Fellowship, Associate Vice Chair for Education and Academic Affairs, University of California San Diego, United States
Dr. Huan-You Wang is a distinguished Clinical Professor of Pathology at the University of California, San Diego (UCSD), where he also serves as the Medical Director of the Clinical Hematology Laboratory. With an extensive career in academic medicine and clinical diagnostics, Dr. Wang has made significant contributions to the field of hematopathology. His research primarily focuses on hematologic malignancies, including leukemia, lymphoma, and myelodysplastic syndromes. Dr. Wang’s expertise encompasses molecular diagnostics, flow cytometry, and the integration of advanced genomic techniques into clinical practice. He has authored over 160 peer-reviewed publications, reflecting his commitment to advancing medical knowledge and improving patient care. Beyond his clinical and research endeavors, Dr. Wang has played a pivotal role in medical education, mentoring numerous trainees and contributing to the development of pathology fellowship programs at UCSD. His leadership extends to professional organizations, having served as the President of the Chinese American Pathologists Association (CAPA) from 2019 to 2020. Dr. Wang’s dedication to excellence in pathology has earned him recognition as a leader in his field, influencing both national and international practices in hematopathology.
Professional Profile
Education
Dr. Wang’s academic journey began at Tongji Medical University in Wuhan, China, where he served as a Graduate Research Associate in the Department of Pathology from 1987 to 1990. He then held an instructor position at Peking University Health Sciences Center in Beijing from 1990 to 1992. Pursuing advanced education, Dr. Wang completed his MD and PhD at the University of California, San Diego, specializing in Molecular Pathology and Cellular and Molecular Medicine between 1994 and 2000. This rigorous training provided him with a robust foundation in both clinical medicine and biomedical research, equipping him with the skills necessary to excel in the complex field of hematopathology. His educational background reflects a blend of international experience and interdisciplinary expertise, contributing to his comprehensive approach to pathology and research.
Professional Experience
Dr. Wang’s professional career is marked by a series of esteemed positions in academic and clinical settings. From 2005 to 2009, he served as an Assistant Professor of Pathology at the University of Texas Southwestern Medical Center in Richardson, Texas. In 2009, he joined the University of California, San Diego, where he currently holds the position of Clinical Professor of Pathology. At UCSD, Dr. Wang also serves as the Medical Director of the Clinical Hematology Laboratory, overseeing diagnostic services and contributing to the advancement of laboratory practices. His roles have encompassed clinical diagnostics, research, and education, reflecting a commitment to integrating scientific discovery with patient care. Dr. Wang’s leadership in these capacities has significantly influenced the development of pathology services and the training of future medical professionals.
Research Interests
Dr. Wang’s research interests are centered on the pathogenesis and diagnosis of hematologic malignancies. He has extensively studied various forms of leukemia and lymphoma, focusing on the molecular and cellular mechanisms underlying these diseases. His work often involves the application of advanced techniques such as flow cytometry, molecular diagnostics, and genomic analysis to improve diagnostic accuracy and patient outcomes. Dr. Wang is particularly interested in the identification of novel biomarkers and therapeutic targets, aiming to enhance personalized medicine approaches in hematopathology. His research contributes to a deeper understanding of disease processes and the development of innovative diagnostic and treatment strategies.
Research Skills
Dr. Wang possesses a comprehensive skill set that encompasses various methodologies essential to modern pathology research. His expertise includes flow cytometry, which he utilizes for immunophenotypic analysis of hematologic malignancies. He is proficient in molecular diagnostic techniques, such as polymerase chain reaction (PCR) and next-generation sequencing (NGS), enabling the detection of genetic mutations and chromosomal abnormalities. Dr. Wang also employs immunohistochemistry for the characterization of tissue samples, contributing to accurate disease classification. His skills extend to the interpretation of complex data sets, integrating clinical findings with laboratory results to inform diagnostic and therapeutic decisions. This multifaceted expertise allows Dr. Wang to conduct comprehensive research that bridges laboratory science and clinical application.
Awards and Honors
Throughout his career, Dr. Wang has received numerous accolades recognizing his contributions to pathology and medical research. Notably, he served as the President of the Chinese American Pathologists Association (CAPA) from 2019 to 2020, reflecting his leadership and commitment to the professional community. His extensive publication record, comprising over 160 peer-reviewed articles, underscores his influence in the field and dedication to advancing scientific knowledge. Dr. Wang’s work has garnered citations and recognition from peers, highlighting the impact of his research on the understanding and management of hematologic diseases. These honors attest to his role as a leading figure in pathology, contributing to both academic excellence and clinical innovation.
Conclusion
Dr. Huan-You Wang’s career exemplifies a harmonious blend of clinical practice, research, and education in the field of pathology. His dedication to understanding hematologic malignancies has led to significant advancements in diagnostic methodologies and patient care. Through his leadership roles, including his tenure as President of CAPA, Dr. Wang has influenced the direction of pathology practice and fostered professional development within the community. His commitment to mentorship and education ensures the cultivation of future experts in the field. Dr. Wang’s contributions continue to shape the landscape of hematopathology, reflecting a career devoted to scientific inquiry, clinical excellence, and the betterment of patient outcomes.
Publications Top Notes
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Title: Isolated Monoclonal T-Cell Receptor Gene Rearrangement in a Lung Adenocarcinoma Harboring MET Exon 14 Skipping: Diagnostic Pitfall
Authors: Shi, Wangpan Jackson; Nguyen, Joshua J.; Song, Wei W.; Fadare, Oluwole O.; Lei, Li L.
Journal: International Journal of Surgical Pathology
Year: 2025
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Title: Intratumoral Injection of Cytotoxic Drugs Plus Hapten Elicits Significant Immune Responses in Sentinel Lymph Nodes: Implications for Cancer Immunotherapy
Authors: Yu, Baofa B.; Zhang, Jian J.; Han, Yan Y.; Zhou, Shengjun S.; Wang, Huanyou H.
Journal: Pancreas
Year: 2025
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Title: Erythroblastic Sarcoma in Adults and Children: Different Pathways to the Same Destination
Authors: Fitzpatrick, Megan J.; Yuan, Ji J.; Capa, Ioana I.; Medeiros, Leonard Jeffrey L.; Pan, Zenggang Z.
Journal: Modern Pathology
Year: 2025
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Title: Mutation in Bruton Tyrosine Kinase (BTK) A428D Confers Resistance to BTK-Degrader Therapy in Chronic Lymphocytic Leukemia
Authors: Wong, Richard L.; Choi, Michael Youngjun M.Y.; Wang, Huanyou H.; Kipps, Thomas J.
Type: Letter
Year: 2025
Citations: 9
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Title: A CD10-Negative Adult B-Lymphoblastic Leukemia with Amplification of KMT2A Without Rearrangement: A Case Report and Review of the English Literature
Authors: Wang, Huanyou H.; Louis, Hailee M.St H.M.S.; Costello, Caitlin L.C.L.; Murray, Sarah Shaw S.S.; Dell’Aquila, Marie L.M.L.
Year: 2025
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Title: Indolent T-Cell/Natural Killer-Cell Lymphomas/Lymphoproliferative Disorders of the Gastrointestinal Tract—What Have We Learned in the Last Decade?
Authors: Wang, Xingen X.; Yin, Weihua W.; Wang, Huanyou H.
Type: Review
Year: 2025
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Title: Nuclear Morphology is Shaped by Loop-Extrusion Programs
Authors: Patta, Indumathi I.; Zand, Maryam M.; Lee, Lindsay L.; Hu, Ming M.; Murre, Cornelis C.
Journal: Nature
Year: 2024
Citations: 3
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Title: IDH2-Mutated Near ETP-ALL with Aggressive Leukemia Cutis and Brisk Response to Venetoclax and Decitabine
Authors: Vaidya, Poorva P.; Wang, Huanyou H.; Don, Michelle D.M.D.; Hinds, Brian R.B.R.; Mangan, James K.J.K.
Journal: Leukemia Research Reports
Year: 2024
Citations: 1
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Title: Myeloid Lineage Switch Following CD7-Targeted Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia
Authors: Aldoss, Ibrahim T.I.T.; Tizro, Parastou P.; Bedi, Davsheen D.; Wang, Huanyou H.; Afkhami, Michelle M.
Journal: Haematologica
Year: 2023
Citations: 3
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Title: A Cell-Level Discriminative Neural Network Model for Diagnosis of Blood Cancers
Authors: Robles, Edgar E.E.; Jin, Ye Y.; Smyth, Padhraic P.; Oak, Jean S.J.S.; Qian, Yu Y.
Journal: Bioinformatics
Year: 2023
Citations: 4