Prof. Dr. Xue-Qiang Wang | Chemistry | Best Researcher Award
Associate Director at Hangzhou Insitutte of Medicine, CAS, China
Prof. Dr. Xue-Qiang Wang is a distinguished researcher and group leader at the Hangzhou Institute of Medical Sciences, Chinese Academy of Sciences (CAS). His expertise lies in developing innovative molecular tools and therapies for precision medicine, particularly in cancer treatment and bioimaging. With a strong academic foundation from leading institutions in China, Spain, and the United States, he has established himself as a leader in chemical and biomedical research. His work focuses on multi-specific aptamer construction, targeted radionuclide drugs, and chemiluminescence probe design. Over the years, he has authored more than 30 high-impact journal publications and received numerous prestigious awards, highlighting his contributions to science and technology. His research has significant implications for precision medicine, offering novel solutions for disease detection and treatment.
Professional Profile
Education
Prof. Dr. Xue-Qiang Wang earned his master’s degree from the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, in 2012. He then pursued his Ph.D. at the Institute of Chemical Research of Catalonia, Spain, completing it in 2015. Following his doctoral studies, he engaged in postdoctoral research at the Massachusetts Institute of Technology (MIT) in the United States from 2016 to 2017. His educational background reflects extensive interdisciplinary training, combining organic chemistry, biomedical sciences, and advanced analytical techniques. This diverse academic experience has enabled him to contribute to cutting-edge research in chemical biology and medical science.
Professional Experience
Dr. Wang’s professional journey began with his postdoctoral research at MIT, where he worked on advanced molecular technologies. In 2017, he joined the College of Chemistry and Chemical Engineering at Hunan University, where he contributed significantly to the Laboratory of Molecular Science and Biomedicine. His tenure at Hunan University allowed him to develop key research projects and mentor young scholars. In 2023, he transitioned to the Hangzhou Institute of Medical Sciences, CAS, where he currently leads a research group dedicated to developing novel biomedical applications. His leadership in this field has positioned him as an influential scientist, driving innovation in targeted therapies and diagnostic tools.
Research Interests
Dr. Wang’s research interests focus on the intersection of chemistry, molecular biology, and medicine. His work primarily revolves around multi-specific aptamer construction for precision cancer therapy, which involves designing nucleic acid-based molecules for targeted drug delivery. Another key area of his research is the development of targeted radionuclide drugs, which use radioactive compounds for cancer treatment. Additionally, he specializes in chemiluminescence probe design, enabling precise bioimaging techniques for disease detection and monitoring. These research interests contribute to advancing molecular medicine, providing new therapeutic and diagnostic solutions.
Research Skills
Dr. Wang possesses extensive expertise in molecular design, synthetic chemistry, and biomedical applications. His skills include nucleic acid aptamer development, radiopharmaceutical synthesis, and chemiluminescence probe engineering. He is proficient in advanced analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and fluorescence imaging. His experience in interdisciplinary collaboration allows him to integrate chemistry, biology, and medical sciences to develop innovative solutions. He also has strong leadership and mentorship skills, guiding research teams and fostering academic excellence. His ability to translate laboratory findings into practical applications makes him a key figure in precision medicine research.
Awards and Honors
Dr. Wang’s contributions to science have earned him several prestigious awards and recognitions. In 2019, he was selected for the Huxiang Young Talents Program, which acknowledges promising researchers. In 2021, he was honored with the Hunan Province Furong Scholars Award Program – Distinguished Professor, recognizing his academic excellence. He received the 2022 Hunan Province Outstanding Youth Project grant, supporting his innovative research. Additionally, he was awarded the 2022 Thieme Chemistry Journals Award for his significant contributions to chemistry. In 2023, he was recognized as a Ministry of Education Young Yangtze Scholar, further solidifying his status as a leading researcher in China.
Conclusion
Prof. Dr. Xue-Qiang Wang is an accomplished scholar with a remarkable academic and professional trajectory. His contributions to molecular science and biomedical research have led to significant advancements in targeted cancer therapy and bioimaging. Through his leadership roles, impactful research publications, and numerous accolades, he has demonstrated excellence in his field. His interdisciplinary expertise in chemistry and medical sciences positions him as a key innovator, driving progress in precision medicine. As he continues to expand his research and collaborations, his work is set to have a lasting impact on healthcare and molecular diagnostics.
Publication Top Notes
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Title: “Development of Polymeric Aptamer Probes for In Vivo Continuous Precision Cancer Targeting”
- Authors: Silin Huang, Yu-Ting He, Xiao-Jing Zhang, Xue-Qiang Wang, Qiang Guo
- Year: 2025
- Source: Materials Chemistry Frontiers
- DOI: 10.1039/D4QM00731J
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Title: “Bisboronic Ester-Enabled Redox-Targeted Cancer Therapy: A Cascade ROS Consumption Approach for Efficient Elimination of Cancer Cells”
- Authors: Silin Huang, Yue Cui, Boqiang Wang, Fang-Jie Liu, Jia-Yi Liu, Wen Shao, Xue-Qiang Wang, Qiang Guo
- Year: 2025
- Source: Journal of Medicinal Chemistry
- DOI: 10.1021/acs.jmedchem.5c00038
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Title: “A Bicyclic Dioxetane Chemiluminescence Nanoprobe for Peroxynitrite Imaging In Vivo”
- Authors: Min Shi, Yun Zhang, Jia-Xing Chen, Yanyuan Wu, Zongping Wang, Peng-Fei Shi, Xudong Jin, Xue-Qiang Wang
- Year: 2024
- Source: Analytical Chemistry
- DOI: 10.1021/acs.analchem.4c04510
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Title: “An Aptamer Glue Enables Hyperefficient Targeted Membrane Protein Degradation”
- Authors: Guo-Rong Zhang, Chi Zhang, Ting Fu, Weihong Tan, Xue-Qiang Wang
- Year: 2024
- Source: JACS Au
- DOI: 10.1021/jacsau.4c00260
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Title: “Polyfluoroalkyl Tag Decoration Enables Significantly Enhanced Tumor Penetration Ability of a PTK7 Targeting Aptamer”
- Authors: Yingying Li, Chi Zhang, Ting Fu, Xue-Qiang Wang, Weihong Tan
- Year: 2024
- Source: Bioconjugate Chemistry
- DOI: 10.1021/acs.bioconjchem.4c00131
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Title: “Ni-Catalyzed Csp2 and Csp3 Coupling for Divergent Bisboronic Ester Synthesis”
- Authors: Yue Cui, Shi-Tang Xu, Cheng-Yu Long, Shen-Huan Li, Jie Shen, Ting Fu, Xin-Hua Xu, Xue-Qiang Wang
- Year: 2024
- Source: Organic Letters
- DOI: 10.1021/acs.orglett.4c00904
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Title: “Cobalt-Catalyzed Selective Hydroboration of 1,3-Enynes with HBpin toward 1,3-Dienylboronate Esters”
- Authors: Yining Jia, Liu Yang, Xueqiang Wang, Wen Yang, Wanxiang Zhao
- Year: 2024
- Source: Organic Letters
- DOI: 10.1021/acs.orglett.4c00899
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Title: “High Contrast Bioimaging of Tumor and Inflammation with a Bicyclic Dioxetane Chemiluminescent Probe”
- Authors: Qian Shang, Shen-Huan Li, Yu-Ting He, Yun Zhang, Ting Fu, Shi-Song Han, Wenshan Huang, Xue-Qiang Wang, Jie-Hua Xu
- Year: 2024
- Source: Analytical Chemistry
- DOI: 10.1021/acs.analchem.3c05062
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Title: “Correction to ‘Ni-Catalyzed Protecting Group Free Diphenic Acid Analog Synthesis'”
- Authors: Bo-Wei Zhao, Liu Yang, Cheng-Yu Long, Han-Lu Li, Yu-Ting He, Xue-Qiang Wang
- Year: 2023
- Source: Organic Letters
- DOI: 10.1021/acs.orglett.3c02514
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Title: “Emission Wavelength-Tunable Bicyclic Dioxetane Chemiluminescent Probes for Precise In Vitro and In Vivo Imaging”
- Authors: Shen-Huan Li, Guo-Rong Zhang, Yu-Ting He, Liu Yang, Han-Lu Li, Cheng-Yu Long, Yue Cui, Xue-Qiang Wang
- Year: 2023
- Source: Analytical Chemistry
- DOI: 10.1021/acs.analchem.3c02126