Xiao-Yi Xiong | Medicine and Dentistry | Best Researcher Award

Mr. Xiao-Yi Xiong | Medicine and Dentistry | Best Researcher Award

Associated Professor from Chengdu University of Traditional Chinese Medicine, China

Xiong Xiaoyi is a distinguished researcher and associate professor specializing in neurology, with a particular focus on neuroprotection and brain injury mechanisms. With a robust academic foundation, he earned his PhD from the Army Medical University in 2018, and his work has earned him recognition as a leading researcher in his field. His academic journey has been complemented by a series of prestigious awards, such as the Sichuan Outstanding Youth Science Fund and the Third Prize in the Shandong Medical Science and Technology Progress Award. Xiong’s research primarily addresses ischemic stroke, intracerebral hemorrhage, and neurodegeneration, making significant strides in understanding molecular mechanisms like lactate production, protein lactylation, and astrocyte functions. As an associate professor at Chengdu University of Traditional Chinese Medicine, he has expanded his influence, integrating traditional Chinese medicine techniques with modern neurobiological research. He has published numerous influential papers, showcasing his expertise in neurochemistry, neuroimmunology, and therapeutic strategies. His multidisciplinary approach has made him an asset to various professional committees, where he actively contributes to advancing the field. Xiong’s combination of research depth, academic leadership, and innovative thinking underscores his status as a prominent figure in neurology.

Professional Profile

Education

Xiong Xiaoyi’s academic journey is marked by rigorous training in clinical medicine and neurology. He completed his undergraduate studies at Luzhou Medical College in 2012, where he developed a strong foundation in clinical medicine. His dedication to advancing his knowledge led him to pursue a Master’s degree at the Second Affiliated Hospital of the Third Military Medical University, completing it in 2015. Building on this, he embarked on a PhD program at the same institution, culminating in his doctoral degree in 2018. His doctoral research focused on neuroprotection in ischemic stroke, and his innovative work earned him numerous accolades, including the title of Outstanding PhD Graduate. His doctoral education enabled him to combine cutting-edge research with clinical applications, laying the groundwork for his future contributions in neurology. Xiong’s educational experiences have not only provided him with technical expertise but also honed his capacity for interdisciplinary collaboration, particularly with traditional Chinese medicine. This combination of formal education and practical experience has equipped him with the tools to pursue pioneering research in neurodegenerative diseases and stroke recovery, positioning him as a leader in the field.

Professional Experience

Xiong Xiaoyi’s professional experience spans both academic and clinical domains, showcasing his versatility and expertise in neurology. After completing his PhD in 2018, he took on the role of lecturer at the Department of Neurology at the Second Affiliated Hospital of the Third Military Medical University, where he contributed to both teaching and research. During this time, Xiong’s clinical experience in stroke management complemented his research on brain injury, allowing him to apply theoretical knowledge in real-world settings. In 2019, he transitioned to an associate professor position at the College of Acupuncture and Tuina at Chengdu University of Traditional Chinese Medicine. Here, he has broadened his research focus to explore how traditional Chinese medicine, such as acupuncture, can complement modern neurobiological therapies. His academic responsibilities also include supervising master’s students, further shaping the next generation of neurology researchers. Throughout his career, Xiong has demonstrated a commitment to advancing both theoretical knowledge and clinical practice, making meaningful contributions to the fields of stroke recovery and neurodegeneration. His dual focus on research and education has allowed him to remain at the forefront of both scientific inquiry and academic mentorship.

Research Interests

Xiong Xiaoyi’s research interests are centered on neuroprotection, brain injury, and neurodegenerative diseases, particularly focusing on ischemic stroke and intracerebral hemorrhage. His work aims to elucidate the molecular and cellular mechanisms underlying brain injury, with a specific focus on astrocyte functions and the role of lactate production in neurodegeneration. A key aspect of his research involves exploring how electroacupuncture can provide neuroprotective effects by modulating metabolic pathways, such as lactylation and succinylation. Xiong is also deeply invested in understanding the pathophysiological processes involved in aging-related brain injuries and the potential for rejuvenation through targeted molecular therapies. His research also extends to studying the activation of glial cells and their role in exacerbating brain injury, as well as investigating how metabolic changes in the brain influence these processes. By bridging the gap between traditional medicine and modern neuroscience, Xiong aims to develop innovative therapeutic strategies that can improve patient outcomes in neurodegenerative diseases. His interdisciplinary research approach, integrating traditional Chinese medicine with neurobiology, sets him apart in his field, allowing for novel insights and potential treatments in the neuroprotective domain.

Research Skills

Xiong Xiaoyi’s research skills are vast and multifaceted, spanning molecular biology, neurochemistry, and neuroimmunology. He possesses expertise in cutting-edge techniques, including proteomics, metabolomics, and bioinformatics, which he uses to unravel the complexities of brain injury and neurodegeneration. His ability to design and execute intricate experiments is demonstrated through his extensive use of animal models, where he investigates ischemic stroke and intracerebral hemorrhage. Xiong’s work also integrates advanced biochemical analyses, including lactate and succinylation profiling, to understand metabolic changes during brain injury. His expertise in neuroinflammation and the roles of astrocytes and glial cells in neurodegeneration further highlights his technical capabilities. Additionally, Xiong’s research often employs traditional Chinese medicine techniques, such as electroacupuncture, to explore their potential neuroprotective effects, bridging modern science with ancient healing practices. His proficiency in these interdisciplinary methodologies enables him to contribute novel insights into therapeutic strategies for stroke recovery and neurodegenerative diseases. Beyond technical skills, Xiong’s leadership in research teams and ability to collaborate with international experts underscores his strong communication and mentorship abilities, making him a well-rounded researcher in his field.

Awards and Honors

Xiong Xiaoyi’s exceptional contributions to neurology and neuroprotection have earned him numerous prestigious awards and honors throughout his career. In 2016, he received the Excellent Master’s Thesis award from both the Third Military Medical University and the PLA, underscoring his early promise in research. His doctoral research earned him the Outstanding PhD Graduate distinction from the Army Medical University in 2018, a testament to the impact of his work in the field of neuroprotection. His innovative contributions have also been recognized by national and provincial authorities, including the Sichuan Outstanding Youth Science Fund and the Sichuan Provincial Special Expert (Young Thousand Talents Program) award in 2021. Xiong’s work has led to multiple accolades in scientific research, such as the Excellent Poster Award at the 12th Chinese Neuroscience Annual Meeting and the Third Prize in the Shandong Medical Science and Technology Progress Award. These honors reflect the high regard in which he is held by the academic and medical communities. His ability to secure competitive funding, including the Chongqing Graduate Research Innovation Fund, further highlights his credibility and standing as a leading researcher in neurology and stroke recovery.

Conclusion

Xiong Xiaoyi is a highly accomplished researcher whose work in neurology has significantly advanced our understanding of stroke, brain injury, and neurodegenerative diseases. His innovative research, spanning both clinical and basic science, has placed him at the forefront of neuroprotective therapies, particularly in the areas of ischemic stroke and intracerebral hemorrhage. Xiong’s ability to integrate traditional Chinese medicine with modern neurobiological approaches sets him apart as a pioneer in his field. His numerous awards and honors, along with his leadership roles in professional societies, highlight his influence and recognition within the academic and medical communities. Xiong’s multidisciplinary research, mentorship, and contributions to the field have solidified his reputation as a leader in neurology, and he continues to make significant strides in developing novel therapeutic strategies. With a clear focus on improving patient outcomes and advancing scientific understanding, Xiong Xiaoyi’s future contributions are poised to leave a lasting impact on neurology and neuroprotective medicine.

Publications Top Notes

  1. Title: Electroacupuncture Pretreatment Reduces Ischemic Brain Injury by Inhibiting the Lactate Production and Its Derived Protein Lactylation Formation
    Authors: X. Pan, Xinru; Y. Zhang, Yaodan; Y.H. Gan, Yuan Hui; Y. Tang, Yong; X. Xiong, Xiaoyi
    Year: 2025
    Journal: CNS Neuroscience and Therapeutics

  2. Title: Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
    Authors: X. Xiong, Xiaoyi; X. Pan, Xinru; X. Luo, Xiaxia; S. Yu, Shuguang; Q.Q. Yang, Qingwu Qian
    Year: 2024
    Citations: 13
    Journal: Theranostics

  3. Title: A Novel Mutation in an MNGIE Patient Presenting with More Prominent Neurological Symptoms than GI Symptoms
    Authors: X. Chen, Xiaoyan; X. Xiong, Xiaoyi; S. Liu, Shu; R. Xu, Rui; Q.Q. Yang, Qingwu Qian
    Year: 2023
    Journal: Neurology India

  4. Title: Metabolomics profiling to characterize cerebral ischemia-reperfusion injury in mice
    Authors: Q. Chen, Qiong; T. Zhou, Ting; J. Yuan, Junjie; C. Liu, Chang; Q.Q. Yang, Qingwu Qian
    Year: 2023
    Citations: 4
    Journal: Frontiers in Pharmacology

 

Claudia Von Arx | Medicine and Dentistry | Best Researcher Award

Dr. Claudia Von Arx | Medicine and Dentistry | Best Researcher Award

Oncology consultant/Researcher of INT IRCCS Fondazione G. Pascale, Italy.

Claudia Von Arx is a dedicated researcher and medical professional with a wealth of experience in oncology research. She completed her medical degree at the University of Naples “Federico II” and subsequently specialized in Medical Oncology. Claudia pursued her passion for research by undertaking a PhD at Imperial College London, focusing on the development of recombinant OPCML tumor suppressor protein as a therapy for ovarian cancer. With extensive experience as a clinical research fellow at prestigious institutions like Imperial College London and INT IRCSS Fondazione G. Pascale of Naples, Claudia has contributed significantly to preclinical and translational research in oncology. Her expertise lies in developing predictive biomarkers, planning and conducting clinical trials, and exploring innovative treatment strategies for various types of cancer. Claudia’s commitment to advancing cancer research and patient care underscores her dedication to improving outcomes in oncology.

Professional Profiles:

Education

Ali Gholizadeh pursued his academic journey with distinction, attaining a Master of Science (2) in Material and Surface Engineering from École Nationale Supérieure d’Arts et Métiers (ENSAM) in 2020. Prior to this, he completed a Master of Science (1) in Mechanical Engineering, with a focus on Fluid Dynamics, also from ENSAM, in 2018. Ali’s educational foundation was laid with a Bachelor of Science in Mechanical Engineering from Shahid Bahonar University of Kerman in 2017. Throughout his academic career, Ali demonstrated exceptional aptitude and dedication, evidenced by his research projects and academic achievements.

Professional Experience

Ali Gholizadeh is an accomplished engineer with a diverse background in research and development. Currently serving as a Research Engineer at the University of Liège, he specializes in the development of innovative chip architectures for biochemical workflows. With previous roles at Fluigent and the Science and Technology Research Center, Ali has honed his skills in microfluidic technologies, CAD design, and data analysis. His academic journey includes a Master’s degree in Material and Surface Engineering from École Nationale Supérieure d’Arts et Métiers and a Bachelor’s degree in Mechanical Engineering from Shahid Bahonar University of Kerman. Throughout his career, Ali has demonstrated a strong commitment to advancing engineering solutions through cutting-edge research and development initiatives.

Research Interest

Ali Gholizadeh’s research interests encompass several areas of engineering, with a primary focus on microfluidic technologies and their applications. He is particularly interested in the design and optimization of microfluidic chips for various biochemical workflows, including sample preparation, analysis, and diagnostics. Additionally, Ali is passionate about exploring novel materials and fabrication techniques to enhance the performance and functionality of microfluidic devices. His research also extends to areas such as lab-on-a-chip systems, high-speed imaging, and instrument interface development. Overall, Ali’s goal is to contribute to the advancement of interdisciplinary research at the intersection of engineering, biology, and medicine, with the ultimate aim of addressing real-world challenges and improving human health.

Award and Honors

Ali Gholizadeh has received several honors and awards in recognition of his contributions to research and academia. Notably, he was selected as a ranked student for participation in a prestigious dual degree program between IUST and ENSAM, where his master’s project received the highest score by the jury. Additionally, he achieved the top 1% rank among 35,000 participants in the nationwide university entrance exam for graduate studies in Mechanical Engineering, earning a full scholarship to study at IUST. These accomplishments highlight Ali’s academic excellence and dedication to his field, positioning him as a promising young researcher in the engineering community.

Research Skills

Ali Gholizadeh possesses a diverse set of research skills that enable him to excel in his field. His expertise includes design and microfabrication of electromechanical instruments and microfluidic chips, along with proficiency in CAD, 3D printing, and software programming for development purposes. He is skilled in data analysis and post-processing, utilizing tools such as MATLAB, Python, and image processing techniques. Additionally, Ali has experience in high-speed imaging and microscopy, contributing to his ability to conduct detailed analysis and observation in his research projects. His critical thinking, problem-solving abilities, and strong teamwork skills further enhance his research capabilities, allowing him to make significant contributions to the advancement of engineering and technology.

Publications

  1. A new schedule of one week on/one week off temozolomide as second-line treatment of advanced neuroendocrine carcinomas (TENEC-TRIAL): a multicenter, open-label, single-arm, phase II trial
    • Authors: C. von Arx, G. Della Vittoria Scarpati, L. Cannella, A. Ottaiano, S. Tafuto
    • Journal: ESMO Open
    • Year: 2024
    • Volume: 9
    • Issue: 5
    • Citations: 0
  2. Cancer genetic counselling for hereditary breast cancer in the era of precision oncology
    • Authors: M. Pensabene, A. Calabrese, C. von Arx, R. Caputo, M. De Laurentiis
    • Journal: Cancer Treatment Reviews
    • Year: 2024
    • Volume: 125
    • Citations: 0
  3. Neratinib as adjuvant therapy in patients with HER2 positive breast cancer: expert opinion
    • Authors: R. Caputo, G. Buono, V.D. Lauro, F. Nuzzo, M. De Laurentiis
    • Journal: Future Oncology
    • Year: 2023
    • Volume: 19
    • Issue: 24
    • Pages: 1695–1708
    • Citations: 0
  4. The Complex Management of the Breast Angiosarcoma: A Retrospective Study
    • Authors: L. Cannella, F. Perri, O. Clemente, A. De Chiara, S. Tafuto
    • Journal: Oncology (Switzerland)
    • Year: 2023
    • Volume: 101
    • Issue: 4
    • Pages: 234–239
    • Citations: 1
  5. The evolving therapeutic landscape of trastuzumab-drug conjugates: Future perspectives beyond HER2-positive breast cancer
    • Authors: C. von Arx, P. De Placido, A. Caltavituro, M. Giuliano, L. Del Mastro
    • Journal: Cancer Treatment Reviews
    • Year: 2023
    • Volume: 113
    • Citations: 17
  6. Male Breast Cancer: From Molecular Genetics to Clinical Management
    • Authors: M. Pensabene, C. Von Arx, M. De Laurentiis
    • Journal: Cancers
    • Year: 2022
    • Volume: 14
    • Issue: 8
    • Pages: 2006
    • Citations: 10
  7. Editorial: The Treatment of RAS or BRAF Mutated Metastatic Colorectal Cancer: Challenges and Perspectives
    • Authors: A. Ottaiano, M. Berretta, C. Von Arx, M. Capozzi, M. Caraglia
    • Journal: Frontiers in Oncology
    • Year: 2022
    • Volume: 12
    • Pages: 852445
    • Citations: 1
  8. Early Identification of Residual Disease After Neuroendocrine Tumor Resection Using a Liquid Biopsy Multigenomic mRNA Signature (NETest)
    • Authors: I.M. Modlin, M. Kidd, K. Oberg, I.A. Drozdov, A. Kitz
    • Journal: Annals of Surgical Oncology
    • Year: 2021
    • Volume: 28
    • Issue: 12
    • Pages: 7506–7517
    • Citations: 24
  9. Selinexor and the selective inhibition of nuclear export: A new perspective on the treatment of sarcomas and other solid and non-solid tumors
    • Authors: A.L. Marretta, G. Di Lorenzo, D. Ribera, A. Pizzolorusso, S. Tafuto
    • Journal: Pharmaceutics
    • Year: 2021
    • Volume: 13
    • Issue: 9
    • Pages: 1522
    • Citations: 2
  10. Uptake of trastuzumab biosimilars for the treatment of HER2-positive breast cancer: A real-world experience from a cancer center
    • Authors: M. Piezzo, R. D’aniello, I. Avallone, M. De Laurentiis, P. Maiolino
    • Journal: Pharmaceutics
    • Year: 2021
    • Volume: 13
    • Issue: 5
    • Pages: 684
    • Citations: 3