Dr. Liton Kumar Saha | Cancer | Excellence in Research

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Dr. Liton Kumar Saha | Cancer | Excellence in Research

Post-doctoral Fellow at Cancer, National Cancer Institute, United States

πŸ‘¨β€πŸŽ“He remarkable academic journey, extensive research contributions, and dedication to the field of psychology are truly commendable. Your wealth of knowledge and diverse skill set reflect a deep commitment to understanding and addressing critical issues such as bullying, inclusion, and socialization.

πŸ”¬ He successful completion of a PhD in Psychology, along with the numerous advanced courses and workshops, showcases your continuous pursuit of excellence and expertise in your field.

πŸ† The awards and recognitions, including the First Place in the Poster Award at the University of Stavanger, underscore the impact of your research and the high regard it holds in the academic community.

Professional Profiles:

Education/Research:

From July 2019 to the present, [Name] has served as a Postdoctoral Fellow (Visiting) at the Developmental Therapeutics Branch, National Cancer Institute, NIH. His research focuses on PARP1, TOP3A, Replication, DNA repair, DNA-protein crosslink, mitochondria, and related topics. He earned his Ph.D. degree in Medical Sciences from the Graduate School of Medicine, Kyoto University, Kyoto, Japan, from 2016 to 2019. His Ph.D. research was conducted in the Department of Radiation Genetics, where he investigated the novel function of genes in DNA repair and DNA damage tolerance. He achieved this by generating mutants in human cell lines using CRISPR/Cas9 and TALEN technology. Prior to his Ph.D., he completed his Master’s degree in medical sciences at the Graduate School of Medicine, Kyoto University, Kyoto, Japan, from 2014 to 2016. His research during this period focused on DNA repair and toxicology, specifically utilizing DNA-repair-deficient cells to identify genotoxins with greater sensitivity and characterizing DNA lesions caused by industrial chemical compounds. He received his Master’s degree in Biochemistry and Molecular Biology from the Faculty of Biological Sciences, University of Dhaka, Dhaka, Bangladesh, in 2007-2008. His dissertation was on the phenotypic and molecular characterization of Salmonella Typhi isolated recently in Bangladesh. He also holds a Bachelor’s degree in Biochemistry and Molecular Biology from the Faculty of Biological Sciences, University of Dhaka, Dhaka, Bangladesh, achieved with distinction, from 2001 to 2006.

πŸ”¬ Visiting Research Associate

  • Dr. Samuel H. Wilson lab
  • Genome Integrity and Structure Biology Laboratory
  • National Institute of Environmental Health Sciences (NIEHS), NIH, USA
  • March 2017-May 2017
  • Research Topic: Established In-vitro base excision repair (BER) of CPD lesion-containing DNA (cell-extract based and enzyme-mediated both).

πŸ”¬ Visiting Research Associate

  • Professor Ian D Hickson lab
  • Center for Chromosome Stability
  • Institute of Cellular and Molecular Medicine
  • Faculty of Health and Medical Sciences
  • University of Copenhagen, Copenhagen, Denmark
  • September 2015- November 2017
  • Research Topic: Performed and established the protocol for the detection of ultrafine DNA bridges (UFBs) in human TK6 cells using MRE11 mutant.

πŸ”¬ Research Assistant

  • Department of Radiation Genetics
  • Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • August 2013- March 2014

πŸ”¬ Research Officer

  • International Center for Diarrheal Diseases Research, Bangladesh (ICDDR, B)
  • Dhaka, Bangladesh
  • 2009-2012

Awards:

During the period of 2014 to 2019, [Name] was awarded a Scholarship from the Training Program of Leaders for Integrated Medical System: for Fruitful Healthy-Longevity Society in Japan. Additionally, in 2018, he received a research grant from the Training Program of Leaders for Integrated Medical System at Kyoto University, Japan. Similarly, in both 2017 and 2016, he was also awarded research grants from the same Training Program at Kyoto University, Japan.

Publications:

  1. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II–DNA complexes
    • Authors: H Sasanuma, M Tsuda, S Morimoto, LK Saha, MM Rahman, Y Kiyooka, …
    • Citations: 81
    • Year: 2018
  2. Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)
    • Authors: Y Sun, S Saha, W Wang, LK Saha, SYN Huang, Y Pommier
    • Citations: 72
    • Year: 2020
  3. Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and enhances the chemotherapeutic activity of widely used DNA damaging agents
    • Authors: U Jo, IS Senatorov, A Zimmermann, LK Saha, Y Murai, SH Kim, …
    • Citations: 64
    • Year: 2021
  4. Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
    • Authors: Y Sun, LK Saha, S Saha, U Jo, Y Pommier
    • Citations: 56
    • Year: 2020
  5. SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
    • Authors: U Jo, Y Murai, S Chakka, L Chen, K Cheng, J Murai, LK Saha, …
    • Citations: 34
    • Year: 2021
  6. Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1–DNA complexes
    • Authors: LK Saha, Y Murai, S Saha, U Jo, M Tsuda, S Takeda, Y Pommier
    • Citations: 22
    • Year: 2021
  7. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells
    • Authors: LK Saha, M Wakasugi, S Akter, R Prasad, SH Wilson, N Shimizu, …
    • Citations: 21
    • Year: 2020
  8. The ARK assay is a sensitive and versatile method for the global detection of DNA-protein crosslinks
    • Authors: Q Hu, N Klages-Mundt, R Wang, E Lynn, LK Saha, H Zhang, M Srivastava, …
    • Citations: 21
    • Year: 2020
  9. UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks
    • Authors: R Akagawa, HT Trinh, LK Saha, M Tsuda, K Hirota, S Yamada, A Shibata, …
    • Citations: 18
    • Year: 2020

 

 

Mr. Liang Gong | Cancer Targeting Treatment | Best Researcher Award

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Mr. Liang Gong | Cancer Targeting Treatment | Best Researcher Award

Post Doctor at Cancer Targeting Treatment , Shenzhen Institute of Advanced Technology, China

πŸ‘¨β€πŸŽ“He remarkable academic journey, extensive research contributions, and dedication to the field of psychology are truly commendable. Your wealth of knowledge and diverse skill set reflect a deep commitment to understanding and addressing critical issues such as bullying, inclusion, and socialization.

πŸ”¬ He successful completion of a PhD in Psychology, along with the numerous advanced courses and workshops, showcases your continuous pursuit of excellence and expertise in your field.

πŸ† The awards and recognitions, including the First Place in the Poster Award at the University of Stavanger, underscore the impact of your research and the high regard it holds in the academic community.

Professional Profiles:

Education:

Mr. Liang Gong pursued his education in biotechnology, earning a Ph.D. from Jiangnan University in Wuxi, Jiangsu, CN (2019-09-06 to 2023-06-13) from the School of Biotechnology. Prior to this, he obtained an MD from Hunan Normal University in Changsha, Hunan, CN (2016-09 to 2019-06) with a focus on the State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science. 😊

Patent & Funding:

Mr. Liang Gong is the inventor of the patent “Ligand-Targeted Cell Conjugate (Ltcc)-Based Anti-Tumor Immune Cell, As Well As Preparation Method And Use Thereof” with the registration number US 17551412. Additionally, he has received funding from the Postgraduate Research and Practice Innovation Program of Jiangsu Province (KYCX21_2021).

Publications:

Reprogramming tumor-associated macrophages by a dually targeted milk exosome system as a potent monotherapy for cancer

An off-the-shelf small extracellular vesicle nanomedicine for tumor targeting therapy

ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer

EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes

A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer

Hyaluronic Acid-Coated Bovine Milk Exosomes for Achieving Tumor-Specific Intracellular Delivery of miRNA-204

Ferroptosis-Associated Molecular Features to Aid Patient Clinical Prognosis and Therapy Across Human Cancers

Ξ²-Galactosidase-dependent metabolic glycoengineering of tumor cells for imaging and immunotherapy

Chemical Synthesis of Antibody-Hapten Conjugates Capable of Recruiting the Endogenous Antibody to Magnify the Fc Effector Immunity of Antibody for Cancer Immunotherapy

Chemoenzymatic Synthesis of a Rhamnose-Functionalized Bispecific Nanobody as a Bispecific Antibody Mimic for Cancer Immunotherapy

 

Mr. Rahul Sharma | Molecular Medicine | Best Researcher Award

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Mr. Rahul Sharma : Leading Researcher in Molecular Medicine

PhD Scholar at Molecular Medicine, Jamia Hamdard, India

He remarkable academic journey, extensive research contributions, and dedication to the field of psychology are truly commendable. Your wealth of knowledge and diverse skill set reflect a deep commitment to understanding and addressing critical issues such as bullying, inclusion, and socialization.

πŸ”¬ He successful completion of a PhD in Psychology, along with the numerous advanced courses and workshops, showcases your continuous pursuit of excellence and expertise in your field.

πŸ† The awards and recognitions, including the First Place in the Poster Award at the University of Stavanger, underscore the impact of your research and the high regard it holds in the academic community.

Professional Profiles:

Education:

Mr. Rahul Sharma is a dedicated researcher with expertise in molecular medicine and biotechnology. In 2023, he submitted his Ph.D. thesis in Molecular Medicine at Jamia Hamdard, New Delhi. His research focused on drug repurposing approaches against methyltransferases of Mycobacterium tuberculosis and alternative therapeutics, under the supervision of Dr. Sonam Grover. Prior to his Ph.D., Mr. Sharma completed his MS in Biotechnology at Jamia Hamdard in 2017. His master’s thesis titled “Molecular characterization and phylogenetic analysis of Rotavirus A, G9 with different P-type combinations including Rotavac vaccine strain G9P[11], 116E” was conducted under the guidance of Professor Pratima Ray. His academic journey reflects a strong commitment to advancing knowledge in the field of molecular medicine and biotechnology. Mr. Rahul Sharma is a researcher specializing in molecular medicine and biotechnology. In 2023, he completed his Ph.D. in Molecular Medicine at Jamia Hamdard, New Delhi, where he focused on drug repurposing approaches against methyltransferases of Mycobacterium tuberculosis and alternative therapeutics. This significant research was conducted under the guidance of Dr. Sonam Grover. Prior to his Ph.D., Mr. Sharma earned his MS in Biotechnology from Jamia Hamdard in 2017. His master’s thesis, supervised by Professor Pratima Ray, was titled “Molecular characterization and phylogenetic analysis of Rotavirus A, G9 with different P-type combinations including Rotavac vaccine strain G9P[11], 116E.” Mr. Sharma’s academic journey showcases his dedication to advancing the field of molecular medicine and biotechnology through rigorous research.

Experience:

In his primary research work, Mr. Rahul Sharma conducted screenings of FDA-approved drugs using computational and biophysical methods against essential enzymes of Mycobacterium tuberculosis. Selected compounds from this screening were then tested for their inhibitory potential on the virulent strain Mtb-H37Rv under both in-vitro and ex-vivo conditions. In his secondary research work, Mr. Sharma focused on immunoinformatics to design a vaccine construct aimed at preventing and treating Mycobacterium tuberculosis infections. This vaccine construct was designed based on the analysis of secretory exosomes antigens of the pathogen, with the goal of developing a preventive therapeutic approach against tuberculosis.

Area of Specialization:

  1. Molecular Cloning
  2. Recombinant protein production
  3. Fluorescence spectroscopy
  4. High-throughput ligand and buffer screening
  5. Protein-ligand interaction thermodynamics
  6. Protein folding and unfolding
  7. Molecular dynamic simulations
  8. Computational Structure-based drug design
  9. Molecular mechanical calculations
  10. Peptide-based vaccine design

Technical skills:

Mr. Rahul Sharma demonstrates proficiency in a variety of technical skills relevant to his research in molecular medicine and biotechnology:

  • Operating Systems: He is experienced in working with UNIX (Ubuntu) and Windows operating systems, showcasing adaptability across different platforms.
  • Programming Languages: He has a foundational understanding of Bash and Python programming languages, which are commonly used in bioinformatics and computational biology.
  • Molecular Dynamics: Mr. Sharma has expertise in using GROMACS for simulating protein-ligand and protein-protein interactions, as well as DESMOND for molecular dynamics simulations.
  • Docking Software: He is skilled in using GLIDE and VINA for molecular docking studies, a crucial aspect of drug discovery and development.
  • Purification Techniques: Mr. Sharma is proficient in the use of Nickel-NTA His-tag affinity chromatography for protein purification, a key step in obtaining high-quality protein samples.

Awards:

Mr. Rahul Sharma has received prestigious accolades and awards that underscore his exceptional contributions and achievements in the field of biotechnology and molecular medicine:

  • 2020 Senior Research Fellowship (SRF), Department of Biotechnology, Government of India: Recognition of his advanced research capabilities and significant contributions to the field, awarded by the esteemed Department of Biotechnology, Government of India.
  • 2018 Junior Research Fellowship (JRF), Department of Biotechnology, Government of India: Acknowledgment of his research potential and early accomplishments in the field, awarded by the Department of Biotechnology, Government of India.
  • 2018 Award for Assistant Professorship, Agricultural Scientists Recruitment Board (ASRB), Government of India: Recognition of his potential for an academic career and teaching excellence, awarded by the Agricultural Scientists Recruitment Board (ASRB), Government of India.